Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
Epithelial cell-cell adhesions are contractile junctions, but whether contractility can be down-regulated is not known. Here the authors report how tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP1 to relax adherens junctions in response to HGF.
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/825f4db4af8b457a93e1d6628f784ef4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|