Non-Coding RNA Networks in Pulmonary Hypertension

Non-coding RNAs (ncRNAs) are involved in various cellular processes. There are several ncRNA classes, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). The detailed roles of these molecules in pulmonary hypertension (PH) remain unclear. We systematically col...

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Autores principales:	Hongbin Zang, Qiongyu Zhang, Xiaodong Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pulmonary hypertension long non-coding RNA circular RNA microRNA network Genetics QH426-470
Acceso en línea:	https://doaj.org/article/825f9203e1bc48d1bcfa6869edcf24c3
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id	oai:doaj.org-article:825f9203e1bc48d1bcfa6869edcf24c3
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spelling	oai:doaj.org-article:825f9203e1bc48d1bcfa6869edcf24c32021-12-01T17:05:03ZNon-Coding RNA Networks in Pulmonary Hypertension1664-802110.3389/fgene.2021.703860https://doaj.org/article/825f9203e1bc48d1bcfa6869edcf24c32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.703860/fullhttps://doaj.org/toc/1664-8021Non-coding RNAs (ncRNAs) are involved in various cellular processes. There are several ncRNA classes, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). The detailed roles of these molecules in pulmonary hypertension (PH) remain unclear. We systematically collected and reviewed reports describing the functions of ncRNAs (miRNAs, lncRNAs, and circRNAs) in PH through database retrieval and manual literature reading. The characteristics of identified articles, especially the experimental methods, were carefully reviewed. Furthermore, regulatory networks were constructed using ncRNAs and their interacting RNAs or genes. These data were extracted from studies on pulmonary arterial smooth muscle cells, pulmonary artery endothelial cells, and pulmonary artery fibroblasts. We included 14 lncRNAs, 1 circRNA, 74 miRNAs, and 110 mRNAs in the constructed networks. Using these networks, herein, we describe the current knowledge on the role of ncRNAs in PH. Moreover, these networks actively provide an improved understanding of the roles of ncRNAs in PH. The results of this study are crucial for the clinical application of ncRNAs.Hongbin ZangQiongyu ZhangXiaodong LiFrontiers Media S.A.articlepulmonary hypertensionlong non-coding RNAcircular RNAmicroRNAnetworkGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulmonary hypertension long non-coding RNA circular RNA microRNA network Genetics QH426-470
spellingShingle	pulmonary hypertension long non-coding RNA circular RNA microRNA network Genetics QH426-470 Hongbin Zang Qiongyu Zhang Xiaodong Li Non-Coding RNA Networks in Pulmonary Hypertension
description	Non-coding RNAs (ncRNAs) are involved in various cellular processes. There are several ncRNA classes, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). The detailed roles of these molecules in pulmonary hypertension (PH) remain unclear. We systematically collected and reviewed reports describing the functions of ncRNAs (miRNAs, lncRNAs, and circRNAs) in PH through database retrieval and manual literature reading. The characteristics of identified articles, especially the experimental methods, were carefully reviewed. Furthermore, regulatory networks were constructed using ncRNAs and their interacting RNAs or genes. These data were extracted from studies on pulmonary arterial smooth muscle cells, pulmonary artery endothelial cells, and pulmonary artery fibroblasts. We included 14 lncRNAs, 1 circRNA, 74 miRNAs, and 110 mRNAs in the constructed networks. Using these networks, herein, we describe the current knowledge on the role of ncRNAs in PH. Moreover, these networks actively provide an improved understanding of the roles of ncRNAs in PH. The results of this study are crucial for the clinical application of ncRNAs.
format	article
author	Hongbin Zang Qiongyu Zhang Xiaodong Li
author_facet	Hongbin Zang Qiongyu Zhang Xiaodong Li
author_sort	Hongbin Zang
title	Non-Coding RNA Networks in Pulmonary Hypertension
title_short	Non-Coding RNA Networks in Pulmonary Hypertension
title_full	Non-Coding RNA Networks in Pulmonary Hypertension
title_fullStr	Non-Coding RNA Networks in Pulmonary Hypertension
title_full_unstemmed	Non-Coding RNA Networks in Pulmonary Hypertension
title_sort	non-coding rna networks in pulmonary hypertension
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/825f9203e1bc48d1bcfa6869edcf24c3
work_keys_str_mv	AT hongbinzang noncodingrnanetworksinpulmonaryhypertension AT qiongyuzhang noncodingrnanetworksinpulmonaryhypertension AT xiaodongli noncodingrnanetworksinpulmonaryhypertension
_version_	1718404759691460608

Non-Coding RNA Networks in Pulmonary Hypertension

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