A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

m6A RNA post-transcriptional modification changes RNA hybridization kinetics. Here the authors show that the methylamino group can adopt syn-conformation pairing with uridine with a mismatch-like conformation in RNA duplex. They also develop a quantitative model that predicts how m6A affects the kin...

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Autores principales:	Bei Liu, Honglue Shi, Atul Rangadurai, Felix Nussbaumer, Chia-Chieh Chu, Kevin Andreas Erharter, David A. Case, Christoph Kreutz, Hashim M. Al-Hashimi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82625506d090481bad2beca7aff5481e
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spelling	oai:doaj.org-article:82625506d090481bad2beca7aff5481e2021-12-02T19:04:01ZA quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions10.1038/s41467-021-25253-82041-1723https://doaj.org/article/82625506d090481bad2beca7aff5481e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25253-8https://doaj.org/toc/2041-1723m6A RNA post-transcriptional modification changes RNA hybridization kinetics. Here the authors show that the methylamino group can adopt syn-conformation pairing with uridine with a mismatch-like conformation in RNA duplex. They also develop a quantitative model that predicts how m6A affects the kinetics of hybridization.Bei LiuHonglue ShiAtul RangaduraiFelix NussbaumerChia-Chieh ChuKevin Andreas ErharterDavid A. CaseChristoph KreutzHashim M. Al-HashimiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bei Liu Honglue Shi Atul Rangadurai Felix Nussbaumer Chia-Chieh Chu Kevin Andreas Erharter David A. Case Christoph Kreutz Hashim M. Al-Hashimi A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
description	m6A RNA post-transcriptional modification changes RNA hybridization kinetics. Here the authors show that the methylamino group can adopt syn-conformation pairing with uridine with a mismatch-like conformation in RNA duplex. They also develop a quantitative model that predicts how m6A affects the kinetics of hybridization.
format	article
author	Bei Liu Honglue Shi Atul Rangadurai Felix Nussbaumer Chia-Chieh Chu Kevin Andreas Erharter David A. Case Christoph Kreutz Hashim M. Al-Hashimi
author_facet	Bei Liu Honglue Shi Atul Rangadurai Felix Nussbaumer Chia-Chieh Chu Kevin Andreas Erharter David A. Case Christoph Kreutz Hashim M. Al-Hashimi
author_sort	Bei Liu
title	A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
title_short	A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
title_full	A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
title_fullStr	A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
title_full_unstemmed	A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
title_sort	quantitative model predicts how m6a reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82625506d090481bad2beca7aff5481e
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A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

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