Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study

Objective To determine how clinical and laboratory factors were associated with nosocomial pneumonia in adult patients hospitalized in an internal medicine department. Methods We conducted a retrospective unmatched case-control study. We recorded clinical and epidemiological data from patients...

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Autores principales:	Gonzalo Huaman Junco, Jhony A. De La Cruz-Vargas
Formato:	article
Lenguaje:	EN ES
Publicado:	Medwave Estudios Limitada 2021
Materias:	nosocomial pneumonia risk factors hypoalbuminemia anemia perú Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8265857a940a472f9a35e91de069abcb
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spelling	oai:doaj.org-article:8265857a940a472f9a35e91de069abcb2021-11-26T15:46:09ZClinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study10.5867/medwave.2021.09.84820717-6384https://doaj.org/article/8265857a940a472f9a35e91de069abcb2021-10-01T00:00:00Zhttps://www.medwave.cl/link.cgi/Medwave/Estudios/Investigacion/8482https://doaj.org/toc/0717-6384Objective To determine how clinical and laboratory factors were associated with nosocomial pneumonia in adult patients hospitalized in an internal medicine department. Methods We conducted a retrospective unmatched case-control study. We recorded clinical and epidemiological data from patients discharged from an internal medicine department of a Peruvian reference hospital, the Hospital Nacional Arzobispo Loayza, between 2016 and 2018. Bivariate and multivariate analyses (using logistic regression models) were performed to obtain crude and adjusted odds ratios with 95% confidence intervals. A P value < 0.05 was considered significant. We calculated the population attributable fraction of the significant variables. Results We analyzed 138 cases and 200 controls, with a mean age of 72.6 ± 17.8 years (21 to 104) for cases and 71.7 ± 15.3 years (19 to 98) for controls. The multivariate analysis indicated that severe anemia (adjusted odds ratio 9.0, confidence interval 95% 1.9 to 43.1, P = 0.01), severe hypoalbuminemia (adjusted odds ratio 4.0, confidence interval 95% 1.2 to 13.8, P = 0.03), altered state of consciousness (adjusted odds ratio 3.6, confidence interval 95% 1.6 to 8.2, P = 0.00), and prior use of antibiotics (adjusted odds ratio 6.3, confidence interval 95% 2.7 to 14.5, P = 0.00) were significantly associated with nosocomial pneumonia. The population attributable fraction found were 41.8% for altered state of consciousness, 33.2% for severe anemia, and 36.3% for severe hypoalbuminemia. Conclusion Clinical and laboratory risk factors associated with nosocomial pneumonia development in adult patients hospitalized in an internal medicine department were severe anemia, severe hypoalbuminemia, altered consciousness, and previous use of antibiotics.Gonzalo Huaman JuncoJhony A. De La Cruz-VargasMedwave Estudios Limitadaarticlenosocomial pneumoniarisk factorshypoalbuminemiaanemiaperúMedicineRMedicine (General)R5-920ENESMedwave, Vol 21, Iss 09, Pp e8482-e8482 (2021)
institution	DOAJ
collection	DOAJ
language	EN ES
topic	nosocomial pneumonia risk factors hypoalbuminemia anemia perú Medicine R Medicine (General) R5-920
spellingShingle	nosocomial pneumonia risk factors hypoalbuminemia anemia perú Medicine R Medicine (General) R5-920 Gonzalo Huaman Junco Jhony A. De La Cruz-Vargas Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study
description	Objective To determine how clinical and laboratory factors were associated with nosocomial pneumonia in adult patients hospitalized in an internal medicine department. Methods We conducted a retrospective unmatched case-control study. We recorded clinical and epidemiological data from patients discharged from an internal medicine department of a Peruvian reference hospital, the Hospital Nacional Arzobispo Loayza, between 2016 and 2018. Bivariate and multivariate analyses (using logistic regression models) were performed to obtain crude and adjusted odds ratios with 95% confidence intervals. A P value < 0.05 was considered significant. We calculated the population attributable fraction of the significant variables. Results We analyzed 138 cases and 200 controls, with a mean age of 72.6 ± 17.8 years (21 to 104) for cases and 71.7 ± 15.3 years (19 to 98) for controls. The multivariate analysis indicated that severe anemia (adjusted odds ratio 9.0, confidence interval 95% 1.9 to 43.1, P = 0.01), severe hypoalbuminemia (adjusted odds ratio 4.0, confidence interval 95% 1.2 to 13.8, P = 0.03), altered state of consciousness (adjusted odds ratio 3.6, confidence interval 95% 1.6 to 8.2, P = 0.00), and prior use of antibiotics (adjusted odds ratio 6.3, confidence interval 95% 2.7 to 14.5, P = 0.00) were significantly associated with nosocomial pneumonia. The population attributable fraction found were 41.8% for altered state of consciousness, 33.2% for severe anemia, and 36.3% for severe hypoalbuminemia. Conclusion Clinical and laboratory risk factors associated with nosocomial pneumonia development in adult patients hospitalized in an internal medicine department were severe anemia, severe hypoalbuminemia, altered consciousness, and previous use of antibiotics.
format	article
author	Gonzalo Huaman Junco Jhony A. De La Cruz-Vargas
author_facet	Gonzalo Huaman Junco Jhony A. De La Cruz-Vargas
author_sort	Gonzalo Huaman Junco
title	Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study
title_short	Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study
title_full	Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study
title_fullStr	Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study
title_full_unstemmed	Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study
title_sort	clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in peru: a case-control study
publisher	Medwave Estudios Limitada
publishDate	2021
url	https://doaj.org/article/8265857a940a472f9a35e91de069abcb
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Clinical and laboratory factors associated with nosocomial pneumonia in adult patients in the internal medicine department of a national hospital in Peru: A case-control study

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