Cellular immune response in convalescents from Ixodes tick-borne borreliosis

Ixodes tick-borne borreliosis is a natural focal transmissive infectious multi-system disease featured with complex pathogenesis, which multiple aspects remain unclarified. The persistence stage during this infection associated with prolonged Borrelia presence in metastatic foci and repeated multipl...

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Autores principales:	T. S. Zaporozhets, S. A. Sokotun, A. I. Simakova, E. V. Persiyanova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	ixodial tick-borne borreliosis specific antibodies immune system cellular immune response Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/82675a0c7931435eb49028e46021438e
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spelling	oai:doaj.org-article:82675a0c7931435eb49028e46021438e2021-11-22T07:09:53ZCellular immune response in convalescents from Ixodes tick-borne borreliosis2220-76192313-739810.15789/2220-7619-2019-5-6-695-702https://doaj.org/article/82675a0c7931435eb49028e46021438e2020-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/688https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Ixodes tick-borne borreliosis is a natural focal transmissive infectious multi-system disease featured with complex pathogenesis, which multiple aspects remain unclarified. The persistence stage during this infection associated with prolonged Borrelia presence in metastatic foci and repeated multiple dissemination is most complicated for clinical practice. It is assumed that the chronic process can be caused by an inadequate immune response associated with activated autoimmune mechanisms leading to emergence of permanent irreversible (degenerative and atrophic) changes in affected organs. Patients who experienced tick-borne borreliosis need dynamic observation for assessing disease prognosis providing a maintenance therapy. The purpose of the study was to evaluate an opportunity of using cellular immunity indices for predicting disease transition to a chronic course.Materials and methods. The study was carried out at the Medical Association of the Far East Branch of the Russian Academy of Sciences. Case report form data, serum and blood plasma samples collected from 22 patients aged 29–83 years old were examined. Immunological examination data from patients with ixodes tick-borne borreliosis (12–18 months after the onset of acute period) were analyzed. Specific IgM and IgG against Borrelia burgdorferi were determined by using the OMNICS diagnostic test system (St. Petersburg). Lymphocyte immunophenotyping was performed on BD FACSCalibur flow cytometer (Becton Dickinson, USA) by using doublelabeled monoclonal antibodies (Beckman Coulter, France).Results. A variability of activated peripheral blood lymphocytes was found in patients with tick-borne borreliosis evidencing about individual immune response. An imbalanced cellular immune response recorded in seronegative convalescents from tick-borne borreliosis, may be an indirect finding of ongoing Borrelia infection. Finding of specific serum IgG and IgM antibodies in convalescents at late stage coupled to impaired immune system is a warning sign presuming a risk to developing autoimmune reactions. Detection of specific IgM antibodies at late timepoint combined with increased immune cytotoxic potential may be referred to a marker of possible disease transition to chronic course.T. S. ZaporozhetsS. A. SokotunA. I. SimakovaE. V. PersiyanovaSankt-Peterburg : NIIÈM imeni Pasteraarticleixodial tick-borne borreliosisspecific antibodiesimmune systemcellular immune responseInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 5-6, Pp 695-702 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	ixodial tick-borne borreliosis specific antibodies immune system cellular immune response Infectious and parasitic diseases RC109-216
spellingShingle	ixodial tick-borne borreliosis specific antibodies immune system cellular immune response Infectious and parasitic diseases RC109-216 T. S. Zaporozhets S. A. Sokotun A. I. Simakova E. V. Persiyanova Cellular immune response in convalescents from Ixodes tick-borne borreliosis
description	Ixodes tick-borne borreliosis is a natural focal transmissive infectious multi-system disease featured with complex pathogenesis, which multiple aspects remain unclarified. The persistence stage during this infection associated with prolonged Borrelia presence in metastatic foci and repeated multiple dissemination is most complicated for clinical practice. It is assumed that the chronic process can be caused by an inadequate immune response associated with activated autoimmune mechanisms leading to emergence of permanent irreversible (degenerative and atrophic) changes in affected organs. Patients who experienced tick-borne borreliosis need dynamic observation for assessing disease prognosis providing a maintenance therapy. The purpose of the study was to evaluate an opportunity of using cellular immunity indices for predicting disease transition to a chronic course.Materials and methods. The study was carried out at the Medical Association of the Far East Branch of the Russian Academy of Sciences. Case report form data, serum and blood plasma samples collected from 22 patients aged 29–83 years old were examined. Immunological examination data from patients with ixodes tick-borne borreliosis (12–18 months after the onset of acute period) were analyzed. Specific IgM and IgG against Borrelia burgdorferi were determined by using the OMNICS diagnostic test system (St. Petersburg). Lymphocyte immunophenotyping was performed on BD FACSCalibur flow cytometer (Becton Dickinson, USA) by using doublelabeled monoclonal antibodies (Beckman Coulter, France).Results. A variability of activated peripheral blood lymphocytes was found in patients with tick-borne borreliosis evidencing about individual immune response. An imbalanced cellular immune response recorded in seronegative convalescents from tick-borne borreliosis, may be an indirect finding of ongoing Borrelia infection. Finding of specific serum IgG and IgM antibodies in convalescents at late stage coupled to impaired immune system is a warning sign presuming a risk to developing autoimmune reactions. Detection of specific IgM antibodies at late timepoint combined with increased immune cytotoxic potential may be referred to a marker of possible disease transition to chronic course.
format	article
author	T. S. Zaporozhets S. A. Sokotun A. I. Simakova E. V. Persiyanova
author_facet	T. S. Zaporozhets S. A. Sokotun A. I. Simakova E. V. Persiyanova
author_sort	T. S. Zaporozhets
title	Cellular immune response in convalescents from Ixodes tick-borne borreliosis
title_short	Cellular immune response in convalescents from Ixodes tick-borne borreliosis
title_full	Cellular immune response in convalescents from Ixodes tick-borne borreliosis
title_fullStr	Cellular immune response in convalescents from Ixodes tick-borne borreliosis
title_full_unstemmed	Cellular immune response in convalescents from Ixodes tick-borne borreliosis
title_sort	cellular immune response in convalescents from ixodes tick-borne borreliosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/82675a0c7931435eb49028e46021438e
work_keys_str_mv	AT tszaporozhets cellularimmuneresponseinconvalescentsfromixodestickborneborreliosis AT sasokotun cellularimmuneresponseinconvalescentsfromixodestickborneborreliosis AT aisimakova cellularimmuneresponseinconvalescentsfromixodestickborneborreliosis AT evpersiyanova cellularimmuneresponseinconvalescentsfromixodestickborneborreliosis
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Cellular immune response in convalescents from Ixodes tick-borne borreliosis

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