Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.

Avian influenza A viruses (IAVs) pose risks to public, agricultural, and wildlife health. Bridge hosts are spillover hosts that share habitat with both maintenance hosts (e.g., mallards) and target hosts (e.g., poultry). We conducted a comprehensive assessment of European starlings (Sturnus vulgaris...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeremy W Ellis, J Jeffrey Root, Loredana M McCurdy, Kevin T Bentler, Nicole L Barrett, Kaci K VanDalen, Katherine L Dirsmith, Susan A Shriner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/82678cb6715b48dbbb6b2a5665e83345
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:82678cb6715b48dbbb6b2a5665e83345
record_format	dspace
spelling	oai:doaj.org-article:82678cb6715b48dbbb6b2a5665e833452021-12-02T20:00:15ZAvian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.1553-73661553-737410.1371/journal.ppat.1009879https://doaj.org/article/82678cb6715b48dbbb6b2a5665e833452021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009879https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Avian influenza A viruses (IAVs) pose risks to public, agricultural, and wildlife health. Bridge hosts are spillover hosts that share habitat with both maintenance hosts (e.g., mallards) and target hosts (e.g., poultry). We conducted a comprehensive assessment of European starlings (Sturnus vulgaris), a common visitor to both urban and agricultural environments, to assess whether this species might act as a potential maintenance or bridge host for IAVs. First, we experimentally inoculated starlings with a wild bird IAV to investigate susceptibility and replication kinetics. Next, we evaluated whether IAV might spill over to starlings from sharing resources with a widespread IAV reservoir host. We accomplished this using a specially designed transmission cage to simulate natural environmental transmission by exposing starlings to water shared with IAV-infected mallards (Anas platyrhynchos). We then conducted a contact study to assess intraspecies transmission between starlings. In the initial experimental infection study, all inoculated starlings shed viral RNA and seroconverted. All starlings in the transmission study became infected and shed RNA at similar levels. All but one of these birds seroconverted, but detectable antibodies were relatively transient, falling to negative levels in a majority of birds by 59 days post contact. None of the contact starlings in the intraspecies transmission experiment became infected. In summary, we demonstrated that starlings may have the potential to act as IAV bridge hosts if they share water with IAV-infected waterfowl. However, starlings are unlikely to act as maintenance hosts due to limited, if any, intraspecies transmission. In addition, starlings have a relatively brief antibody response which should be considered when interpreting serology from field samples. Further study is needed to evaluate the potential for transmission from starlings to poultry, a possibility enhanced by starling's behavioral trait of forming very large flocks which can descend on poultry facilities when natural resources are scarce.Jeremy W EllisJ Jeffrey RootLoredana M McCurdyKevin T BentlerNicole L BarrettKaci K VanDalenKatherine L DirsmithSusan A ShrinerPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 8, p e1009879 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Jeremy W Ellis J Jeffrey Root Loredana M McCurdy Kevin T Bentler Nicole L Barrett Kaci K VanDalen Katherine L Dirsmith Susan A Shriner Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.
description	Avian influenza A viruses (IAVs) pose risks to public, agricultural, and wildlife health. Bridge hosts are spillover hosts that share habitat with both maintenance hosts (e.g., mallards) and target hosts (e.g., poultry). We conducted a comprehensive assessment of European starlings (Sturnus vulgaris), a common visitor to both urban and agricultural environments, to assess whether this species might act as a potential maintenance or bridge host for IAVs. First, we experimentally inoculated starlings with a wild bird IAV to investigate susceptibility and replication kinetics. Next, we evaluated whether IAV might spill over to starlings from sharing resources with a widespread IAV reservoir host. We accomplished this using a specially designed transmission cage to simulate natural environmental transmission by exposing starlings to water shared with IAV-infected mallards (Anas platyrhynchos). We then conducted a contact study to assess intraspecies transmission between starlings. In the initial experimental infection study, all inoculated starlings shed viral RNA and seroconverted. All starlings in the transmission study became infected and shed RNA at similar levels. All but one of these birds seroconverted, but detectable antibodies were relatively transient, falling to negative levels in a majority of birds by 59 days post contact. None of the contact starlings in the intraspecies transmission experiment became infected. In summary, we demonstrated that starlings may have the potential to act as IAV bridge hosts if they share water with IAV-infected waterfowl. However, starlings are unlikely to act as maintenance hosts due to limited, if any, intraspecies transmission. In addition, starlings have a relatively brief antibody response which should be considered when interpreting serology from field samples. Further study is needed to evaluate the potential for transmission from starlings to poultry, a possibility enhanced by starling's behavioral trait of forming very large flocks which can descend on poultry facilities when natural resources are scarce.
format	article
author	Jeremy W Ellis J Jeffrey Root Loredana M McCurdy Kevin T Bentler Nicole L Barrett Kaci K VanDalen Katherine L Dirsmith Susan A Shriner
author_facet	Jeremy W Ellis J Jeffrey Root Loredana M McCurdy Kevin T Bentler Nicole L Barrett Kaci K VanDalen Katherine L Dirsmith Susan A Shriner
author_sort	Jeremy W Ellis
title	Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.
title_short	Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.
title_full	Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.
title_fullStr	Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.
title_full_unstemmed	Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.
title_sort	avian influenza a virus susceptibility, infection, transmission, and antibody kinetics in european starlings.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/82678cb6715b48dbbb6b2a5665e83345
work_keys_str_mv	AT jeremywellis avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings AT jjeffreyroot avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings AT loredanammccurdy avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings AT kevintbentler avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings AT nicolelbarrett avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings AT kacikvandalen avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings AT katherineldirsmith avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings AT susanashriner avianinfluenzaavirussusceptibilityinfectiontransmissionandantibodykineticsineuropeanstarlings
_version_	1718375733497167872

Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings.

Ejemplares similares