Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.

<h4>Introduction</h4>Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients...

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Autores principales:	Anna Gvozdjáková, Zuzana Sumbalová, Jarmila Kucharská, Monika Szamosová, Lubica Čápová, Zuzana Rausová, Oľga Vančová, Viliam Mojto, Peter Langsjoen, Patrik Palacka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/826ea839ccf9452890e83a021944178f
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spelling	oai:doaj.org-article:826ea839ccf9452890e83a021944178f2021-12-02T20:07:58ZPlatelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.1932-620310.1371/journal.pone.0256135https://doaj.org/article/826ea839ccf9452890e83a021944178f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256135https://doaj.org/toc/1932-6203<h4>Introduction</h4>Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyperactivity and thrombosis. In this pilot study we evaluated platelet mitochondrial bioenergy function, CoQ10 levels and oxidative stress in RA patients.<h4>Methods</h4>Twenty-one RA patients and 19 healthy volunteers participated in the study. High resolution respirometry (HRR) was used for analysis of platelet mitochondrial bioenergetics. CoQ10 was determined by HPLC method; TBARS were detected spectrophotometrically.<h4>Results</h4>Slight dysfunction in platelet mitochondrial respiration and reduced platelet CoQ10 levels were observed in RA patients compared with normal controls.<h4>Conclusions</h4>The observed decrease in platelet CoQ10 levels may lead to platelet mitochondrial dysfunction in RA diseases. Determination of platelet mitochondrial function and platelet CoQ10 levels could be used as new diagnostic strategies for mitochondrial bioenergetics in rheumatoid diseases.Anna GvozdjákováZuzana SumbalováJarmila KucharskáMonika SzamosováLubica ČápováZuzana RausováOľga VančováViliam MojtoPeter LangsjoenPatrik PalackaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256135 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Gvozdjáková Zuzana Sumbalová Jarmila Kucharská Monika Szamosová Lubica Čápová Zuzana Rausová Oľga Vančová Viliam Mojto Peter Langsjoen Patrik Palacka Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
description	<h4>Introduction</h4>Rheumatoid arthritis (RA) is a chronic inflammatory autoimunne disorder affecting both small and large synovial joints, leading to their destruction. Platelet biomarkers are involved in inflammation in RA patients. Increased circulating platelet counts in RA patients may contribute to platelet hyperactivity and thrombosis. In this pilot study we evaluated platelet mitochondrial bioenergy function, CoQ10 levels and oxidative stress in RA patients.<h4>Methods</h4>Twenty-one RA patients and 19 healthy volunteers participated in the study. High resolution respirometry (HRR) was used for analysis of platelet mitochondrial bioenergetics. CoQ10 was determined by HPLC method; TBARS were detected spectrophotometrically.<h4>Results</h4>Slight dysfunction in platelet mitochondrial respiration and reduced platelet CoQ10 levels were observed in RA patients compared with normal controls.<h4>Conclusions</h4>The observed decrease in platelet CoQ10 levels may lead to platelet mitochondrial dysfunction in RA diseases. Determination of platelet mitochondrial function and platelet CoQ10 levels could be used as new diagnostic strategies for mitochondrial bioenergetics in rheumatoid diseases.
format	article
author	Anna Gvozdjáková Zuzana Sumbalová Jarmila Kucharská Monika Szamosová Lubica Čápová Zuzana Rausová Oľga Vančová Viliam Mojto Peter Langsjoen Patrik Palacka
author_facet	Anna Gvozdjáková Zuzana Sumbalová Jarmila Kucharská Monika Szamosová Lubica Čápová Zuzana Rausová Oľga Vančová Viliam Mojto Peter Langsjoen Patrik Palacka
author_sort	Anna Gvozdjáková
title	Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
title_short	Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
title_full	Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
title_fullStr	Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
title_full_unstemmed	Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
title_sort	platelet mitochondrial respiration and coenzyme q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/826ea839ccf9452890e83a021944178f
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Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases.

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