Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients

Abstract The objectives of this study were to assess the fat fraction (FF) and cross-sectional area (CSA) of the sciatic nerve in Charcot-Marie-Tooth disease type 1A (CMT1A) patients using Dixon-based proton density fat quantification MRI and to elucidate its potential association with clinical para...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyun Su Kim, Ji Hyun Lee, Young Cheol Yoon, Min Jae Cha, Soo Hyun Nam, Hye Mi Kwon, Seonwoo Kim, Hojeong Won, Byung-Ok Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/826fbea9acd040d7aa6284b880f49b5b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:826fbea9acd040d7aa6284b880f49b5b
record_format	dspace
spelling	oai:doaj.org-article:826fbea9acd040d7aa6284b880f49b5b2021-11-08T10:51:37ZIntraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients10.1038/s41598-021-00819-02045-2322https://doaj.org/article/826fbea9acd040d7aa6284b880f49b5b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00819-0https://doaj.org/toc/2045-2322Abstract The objectives of this study were to assess the fat fraction (FF) and cross-sectional area (CSA) of the sciatic nerve in Charcot-Marie-Tooth disease type 1A (CMT1A) patients using Dixon-based proton density fat quantification MRI and to elucidate its potential association with clinical parameters. Thigh MRIs of 18 CMT1A patients and 18 age- and sex-matched volunteers enrolled for a previous study were reviewed. Analyses for FF and CSA of the sciatic nerve were performed at three levels (proximal to distal). CSA and FF were compared between the two groups and among the different levels within each group. The relationship between the MRI parameters and clinical data were assessed in the CMT1A patients. The CMT1A patients showed significantly higher FF at level 3 (p = 0.0217) and significantly larger CSA at all three levels compared with the control participants (p < 0.0001). Comparisons among levels showed significantly higher FF for levels 2 and 3 than for level 1 and significantly larger CSA for level 2 compared with level 1 in CMT1A patients. CSA at level 3 correlated positively with the CMT neuropathy score version 2 (CMTNSv2). In conclusion, the sciatic nerve FF of CMT1A patients was significantly higher on level 3 compared with both the controls and the measurements taken on more proximal levels, suggesting the possibility of increased intraepineurial fat within the sciatic nerves of CMT1A patients, with a possible distal tendency. Sciatic nerve CSA at level 3 correlated significantly and positively with CMTNSv2, suggesting its potential value as an imaging marker for clinical severity.Hyun Su KimJi Hyun LeeYoung Cheol YoonMin Jae ChaSoo Hyun NamHye Mi KwonSeonwoo KimHojeong WonByung-Ok ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyun Su Kim Ji Hyun Lee Young Cheol Yoon Min Jae Cha Soo Hyun Nam Hye Mi Kwon Seonwoo Kim Hojeong Won Byung-Ok Choi Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients
description	Abstract The objectives of this study were to assess the fat fraction (FF) and cross-sectional area (CSA) of the sciatic nerve in Charcot-Marie-Tooth disease type 1A (CMT1A) patients using Dixon-based proton density fat quantification MRI and to elucidate its potential association with clinical parameters. Thigh MRIs of 18 CMT1A patients and 18 age- and sex-matched volunteers enrolled for a previous study were reviewed. Analyses for FF and CSA of the sciatic nerve were performed at three levels (proximal to distal). CSA and FF were compared between the two groups and among the different levels within each group. The relationship between the MRI parameters and clinical data were assessed in the CMT1A patients. The CMT1A patients showed significantly higher FF at level 3 (p = 0.0217) and significantly larger CSA at all three levels compared with the control participants (p < 0.0001). Comparisons among levels showed significantly higher FF for levels 2 and 3 than for level 1 and significantly larger CSA for level 2 compared with level 1 in CMT1A patients. CSA at level 3 correlated positively with the CMT neuropathy score version 2 (CMTNSv2). In conclusion, the sciatic nerve FF of CMT1A patients was significantly higher on level 3 compared with both the controls and the measurements taken on more proximal levels, suggesting the possibility of increased intraepineurial fat within the sciatic nerves of CMT1A patients, with a possible distal tendency. Sciatic nerve CSA at level 3 correlated significantly and positively with CMTNSv2, suggesting its potential value as an imaging marker for clinical severity.
format	article
author	Hyun Su Kim Ji Hyun Lee Young Cheol Yoon Min Jae Cha Soo Hyun Nam Hye Mi Kwon Seonwoo Kim Hojeong Won Byung-Ok Choi
author_facet	Hyun Su Kim Ji Hyun Lee Young Cheol Yoon Min Jae Cha Soo Hyun Nam Hye Mi Kwon Seonwoo Kim Hojeong Won Byung-Ok Choi
author_sort	Hyun Su Kim
title	Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients
title_short	Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients
title_full	Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients
title_fullStr	Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients
title_full_unstemmed	Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients
title_sort	intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using mri in charcot-marie-tooth disease type 1a patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/826fbea9acd040d7aa6284b880f49b5b
work_keys_str_mv	AT hyunsukim intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT jihyunlee intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT youngcheolyoon intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT minjaecha intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT soohyunnam intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT hyemikwon intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT seonwookim intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT hojeongwon intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients AT byungokchoi intraepineurialfatquantificationandcrosssectionalareaanalysisofthesciaticnerveusingmriincharcotmarietoothdiseasetype1apatients
_version_	1718442541158760448

Intraepineurial fat quantification and cross-sectional area analysis of the sciatic nerve using MRI in Charcot-Marie-Tooth disease type 1A patients

Ejemplares similares