Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls

Galen Chan,1 Tea Rosic,2,3 Stanislav Pasyk,2 Mahshid Dehghan,4 Zainab Samaan2,3 1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; 2Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada; 3Department of Health Resea...

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Autores principales:	Chan G, Rosic T, Pasyk S, Dehghan M, Samaan Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	bdnf psychiatric disorders physical activity diet behavioral risk factors depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8270ec0b9c6d40d2abfec8cfe8c13c65
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spelling	oai:doaj.org-article:8270ec0b9c6d40d2abfec8cfe8c13c652021-12-02T14:12:01ZExploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls1178-2021https://doaj.org/article/8270ec0b9c6d40d2abfec8cfe8c13c652021-02-01T00:00:00Zhttps://www.dovepress.com/exploring-the-impact-of-modifiable-factors-on-serum-bdnf-in-psychiatri-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Galen Chan,1 Tea Rosic,2,3 Stanislav Pasyk,2 Mahshid Dehghan,4 Zainab Samaan2,3 1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; 2Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada; 3Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; 4Population Health Research Institute, McMaster University, Hamilton, Ontario, CanadaCorrespondence: Zainab Samaan Department of Psychiatry and Behavioural NeurosciencesMcMaster University, Hamilton, ON, CanadaTel +1 905 522 1155 ext. 39215Fax +1 905 528 2814Email samaanz@mcmaster.caBackground: Brain-derived neurotrophic factor (BDNF) has been a focus of psychiatric research for the past two decades. BDNF has been shown to impact neural function and development. Studies have investigated serum BDNF as a biomarker for psychiatric disorders such as depression and schizophrenia. In some studies, investigators attempt to control for variables such as smoking status, exercise, or diet. However, the relationship between these factors and BDNF is not clearly established. Furthermore, some studies have questioned whether a difference in the impact of BDNF exists between psychiatric and healthy populations.Purpose: We aim to examine the association between serum BDNF levels and modifiable risk factors such as body mass index (BMI), smoking, exercise levels, and diet. Subsequently, we aim to examine whether the relationship between these risk factors and serum BDNF is different between psychiatric and control populations.Patients and Methods: We use cross-sectional data from an age- and sex-matched case–control study of participants with psychiatric inpatients and community controls without psychiatric diagnoses. Participants completed comprehensive assessments at study enrolment including sociodemographic information, smoking status, exercise, diet, and BMI. Serum BDNF levels were collected from participants. Linear regression analysis was performed to determine the association between modifiable factors and serum BDNF level.Results: A significant association was found between sedentary activity level and lower serum BDNF levels (Beta coefficient = – 2.49, 95% confidence interval [CI] – 4.70, – 0.28, p = 0.028). Subgroup analysis demonstrated that this association held for psychiatric inpatients but not for community controls; it also held in females (Beta coefficient = – 3.18, 95% CI – 6.29, – 0.07, p = 0.045) but not in males (Beta coefficient = – 1.42, 95% CI – 4.61, 1.78, p = 0.383). Antidepressant use had a significantly different association between male (Beta coefficient = 3.20, 95% CI 0.51, 5.88, p = 0.020) and female subgroups (Beta coefficient = – 3.10, 95% CI – 5.75, – 0.46, p = 0.022). No significant association was found between other factors and serum BDNF.Conclusion: Sedentary activity level may lead to lower serum BDNF levels in individuals with psychiatric diagnoses. Our findings support the notion that physical activity can provide a positive impact as part of treatment for psychiatric illness.Keywords: BDNF, psychiatric disorders, physical activity, diet, behavioral risk factors, depressionChan GRosic TPasyk SDehghan MSamaan ZDove Medical Pressarticlebdnfpsychiatric disordersphysical activitydietbehavioral risk factorsdepressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 545-554 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bdnf psychiatric disorders physical activity diet behavioral risk factors depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bdnf psychiatric disorders physical activity diet behavioral risk factors depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chan G Rosic T Pasyk S Dehghan M Samaan Z Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls
description	Galen Chan,1 Tea Rosic,2,3 Stanislav Pasyk,2 Mahshid Dehghan,4 Zainab Samaan2,3 1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; 2Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada; 3Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; 4Population Health Research Institute, McMaster University, Hamilton, Ontario, CanadaCorrespondence: Zainab Samaan Department of Psychiatry and Behavioural NeurosciencesMcMaster University, Hamilton, ON, CanadaTel +1 905 522 1155 ext. 39215Fax +1 905 528 2814Email samaanz@mcmaster.caBackground: Brain-derived neurotrophic factor (BDNF) has been a focus of psychiatric research for the past two decades. BDNF has been shown to impact neural function and development. Studies have investigated serum BDNF as a biomarker for psychiatric disorders such as depression and schizophrenia. In some studies, investigators attempt to control for variables such as smoking status, exercise, or diet. However, the relationship between these factors and BDNF is not clearly established. Furthermore, some studies have questioned whether a difference in the impact of BDNF exists between psychiatric and healthy populations.Purpose: We aim to examine the association between serum BDNF levels and modifiable risk factors such as body mass index (BMI), smoking, exercise levels, and diet. Subsequently, we aim to examine whether the relationship between these risk factors and serum BDNF is different between psychiatric and control populations.Patients and Methods: We use cross-sectional data from an age- and sex-matched case–control study of participants with psychiatric inpatients and community controls without psychiatric diagnoses. Participants completed comprehensive assessments at study enrolment including sociodemographic information, smoking status, exercise, diet, and BMI. Serum BDNF levels were collected from participants. Linear regression analysis was performed to determine the association between modifiable factors and serum BDNF level.Results: A significant association was found between sedentary activity level and lower serum BDNF levels (Beta coefficient = – 2.49, 95% confidence interval [CI] – 4.70, – 0.28, p = 0.028). Subgroup analysis demonstrated that this association held for psychiatric inpatients but not for community controls; it also held in females (Beta coefficient = – 3.18, 95% CI – 6.29, – 0.07, p = 0.045) but not in males (Beta coefficient = – 1.42, 95% CI – 4.61, 1.78, p = 0.383). Antidepressant use had a significantly different association between male (Beta coefficient = 3.20, 95% CI 0.51, 5.88, p = 0.020) and female subgroups (Beta coefficient = – 3.10, 95% CI – 5.75, – 0.46, p = 0.022). No significant association was found between other factors and serum BDNF.Conclusion: Sedentary activity level may lead to lower serum BDNF levels in individuals with psychiatric diagnoses. Our findings support the notion that physical activity can provide a positive impact as part of treatment for psychiatric illness.Keywords: BDNF, psychiatric disorders, physical activity, diet, behavioral risk factors, depression
format	article
author	Chan G Rosic T Pasyk S Dehghan M Samaan Z
author_facet	Chan G Rosic T Pasyk S Dehghan M Samaan Z
author_sort	Chan G
title	Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls
title_short	Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls
title_full	Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls
title_fullStr	Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls
title_full_unstemmed	Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls
title_sort	exploring the impact of modifiable factors on serum bdnf in psychiatric patients and community controls
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8270ec0b9c6d40d2abfec8cfe8c13c65
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Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls

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