Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study

Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study

Abstract Background An association has been identified between mitral valve prolapse (MVP) and sudden cardiac arrest (SCA), and ventricular arrhythmias (VA). This study aimed to elucidate predictive factors for SCA or VA in MVP patients. Methods MVP patients who underwent cardiac magnetic resonance...

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Autores principales: Jae-Hyuk Lee, Jae-Sun Uhm, Young Joo Suh, Min Kim, In-Soo Kim, Moo-Nyun Jin, Min Soo Cho, Hee Tae Yu, Tae-Hoon Kim, Yoo Jin Hong, Hye-Jeong Lee, Chi Young Shim, Young Jin Kim, Jun Kim, Jong-Youn Kim, Boyoung Joung, Geu-Ru Hong, Hui-Nam Pak, Gi-Byoung Nam, Kee-Joon Choi, You-Ho Kim, Moon-Hyoung Lee
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Arrhythmia
Gadolinium
Magnetic resonance imaging
Mitral valve prolapse
Sudden cardiac death
Ventricular tachycardia
Diseases of the circulatory (Cardiovascular) system
RC666-701
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spelling oai:doaj.org-article:8272f12daa6b4dc29f269283443b82cb2021-11-21T12:03:59ZUsefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study10.1186/s12872-021-02362-21471-2261https://doaj.org/article/8272f12daa6b4dc29f269283443b82cb2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02362-2https://doaj.org/toc/1471-2261Abstract Background An association has been identified between mitral valve prolapse (MVP) and sudden cardiac arrest (SCA), and ventricular arrhythmias (VA). This study aimed to elucidate predictive factors for SCA or VA in MVP patients. Methods MVP patients who underwent cardiac magnetic resonance (CMR) were retrospectively included. Patients with other structural heart disease or causes of aborted SCA were excluded. Clinical characteristics (sex, age, body mass index, histories of diabetes, hypertension, and dyslipidemia) and electrocardiographic (PR interval, QRS duration, corrected QT interval, inverted T wave in the inferior leads, bundle branch block, and atrial fibrillation), echocardiographic [mitral regurgitation grade, prolapsing mitral leaflet, and right ventricular systolic pressure (RVSP)], and CMR [left atrial volume index, both ventricular ejection fractions, both ventricular end-diastolic and systolic volume indexes, prolapse distance, mitral annular disjunction, systolic curling motion, presence of late gadolinium enhancement (LGE), LGE volume and proportion] parameters were analyzed. Results Of the 85 patients [age, 54.0 (41.0–65.0) years; 46 men], seven experienced SCA or VA. Younger age and wide QRS complex were observed more often in the SCA/VA group than in the no-SCA/VA group. The SCA/VA group exhibited lower RVSP, more systolic curling motion and LGE, greater LGE volume, and higher LGE proportion. The presence of LGE [hazard ratio (HR), 19.8; 95% confidence interval (CI) 2.65–148.15; P = 0.004], LGE volume (HR 1.08; 95% CI 1.02–1.14; P = 0.006) and LGE proportion (HR 1.32; 95% CI 1.08–1.60; P = 0.006) were independently associated with higher risk of SCA or VA in MVP patients together with systolic curling motion in each model. Conclusions The presence of systolic curling motion, high LGE volume and proportion, and the presence of LGE on CMR were independent predictive factors for SCA or VA in MVP patients.Jae-Hyuk LeeJae-Sun UhmYoung Joo SuhMin KimIn-Soo KimMoo-Nyun JinMin Soo ChoHee Tae YuTae-Hoon KimYoo Jin HongHye-Jeong LeeChi Young ShimYoung Jin KimJun KimJong-Youn KimBoyoung JoungGeu-Ru HongHui-Nam PakGi-Byoung NamKee-Joon ChoiYou-Ho KimMoon-Hyoung LeeBMCarticleArrhythmiaGadoliniumMagnetic resonance imagingMitral valve prolapseSudden cardiac deathVentricular tachycardiaDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Arrhythmia
Gadolinium
Magnetic resonance imaging
Mitral valve prolapse
Sudden cardiac death
Ventricular tachycardia
Diseases of the circulatory (Cardiovascular) system
RC666-701
spellingShingle Arrhythmia
Gadolinium
Magnetic resonance imaging
Mitral valve prolapse
Sudden cardiac death
Ventricular tachycardia
Diseases of the circulatory (Cardiovascular) system
RC666-701
Jae-Hyuk Lee
Jae-Sun Uhm
Young Joo Suh
Min Kim
In-Soo Kim
Moo-Nyun Jin
Min Soo Cho
Hee Tae Yu
Tae-Hoon Kim
Yoo Jin Hong
Hye-Jeong Lee
Chi Young Shim
Young Jin Kim
Jun Kim
Jong-Youn Kim
Boyoung Joung
Geu-Ru Hong
Hui-Nam Pak
Gi-Byoung Nam
Kee-Joon Choi
You-Ho Kim
Moon-Hyoung Lee
Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study
description Abstract Background An association has been identified between mitral valve prolapse (MVP) and sudden cardiac arrest (SCA), and ventricular arrhythmias (VA). This study aimed to elucidate predictive factors for SCA or VA in MVP patients. Methods MVP patients who underwent cardiac magnetic resonance (CMR) were retrospectively included. Patients with other structural heart disease or causes of aborted SCA were excluded. Clinical characteristics (sex, age, body mass index, histories of diabetes, hypertension, and dyslipidemia) and electrocardiographic (PR interval, QRS duration, corrected QT interval, inverted T wave in the inferior leads, bundle branch block, and atrial fibrillation), echocardiographic [mitral regurgitation grade, prolapsing mitral leaflet, and right ventricular systolic pressure (RVSP)], and CMR [left atrial volume index, both ventricular ejection fractions, both ventricular end-diastolic and systolic volume indexes, prolapse distance, mitral annular disjunction, systolic curling motion, presence of late gadolinium enhancement (LGE), LGE volume and proportion] parameters were analyzed. Results Of the 85 patients [age, 54.0 (41.0–65.0) years; 46 men], seven experienced SCA or VA. Younger age and wide QRS complex were observed more often in the SCA/VA group than in the no-SCA/VA group. The SCA/VA group exhibited lower RVSP, more systolic curling motion and LGE, greater LGE volume, and higher LGE proportion. The presence of LGE [hazard ratio (HR), 19.8; 95% confidence interval (CI) 2.65–148.15; P = 0.004], LGE volume (HR 1.08; 95% CI 1.02–1.14; P = 0.006) and LGE proportion (HR 1.32; 95% CI 1.08–1.60; P = 0.006) were independently associated with higher risk of SCA or VA in MVP patients together with systolic curling motion in each model. Conclusions The presence of systolic curling motion, high LGE volume and proportion, and the presence of LGE on CMR were independent predictive factors for SCA or VA in MVP patients.
format article
author Jae-Hyuk Lee
Jae-Sun Uhm
Young Joo Suh
Min Kim
In-Soo Kim
Moo-Nyun Jin
Min Soo Cho
Hee Tae Yu
Tae-Hoon Kim
Yoo Jin Hong
Hye-Jeong Lee
Chi Young Shim
Young Jin Kim
Jun Kim
Jong-Youn Kim
Boyoung Joung
Geu-Ru Hong
Hui-Nam Pak
Gi-Byoung Nam
Kee-Joon Choi
You-Ho Kim
Moon-Hyoung Lee
author_facet Jae-Hyuk Lee
Jae-Sun Uhm
Young Joo Suh
Min Kim
In-Soo Kim
Moo-Nyun Jin
Min Soo Cho
Hee Tae Yu
Tae-Hoon Kim
Yoo Jin Hong
Hye-Jeong Lee
Chi Young Shim
Young Jin Kim
Jun Kim
Jong-Youn Kim
Boyoung Joung
Geu-Ru Hong
Hui-Nam Pak
Gi-Byoung Nam
Kee-Joon Choi
You-Ho Kim
Moon-Hyoung Lee
author_sort Jae-Hyuk Lee
title Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study
title_short Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study
title_full Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study
title_fullStr Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study
title_full_unstemmed Usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study
title_sort usefulness of cardiac magnetic resonance images for prediction of sudden cardiac arrest in patients with mitral valve prolapse: a multicenter retrospective cohort study
publisher BMC
publishDate 2021
url https://doaj.org/article/8272f12daa6b4dc29f269283443b82cb
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