Different states of synaptotagmin regulate evoked versus spontaneous release

Synaptotagmin contains tandem Ca2+-binding C2-domains that interact with target membranes to trigger exocytosis. Here, Bai et al. manipulate the relative orientation of these two domains using a synthetic polyproline linker and show that a parallel orientation is most effective for membrane interact...

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Autores principales:	Hua Bai, Renhao Xue, Huan Bao, Leili Zhang, Arun Yethiraj, Qiang Cui, Edwin R. Chapman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8274240c07f040b09908063f897c0987
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id	oai:doaj.org-article:8274240c07f040b09908063f897c0987
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spelling	oai:doaj.org-article:8274240c07f040b09908063f897c09872021-12-02T14:38:56ZDifferent states of synaptotagmin regulate evoked versus spontaneous release10.1038/ncomms109712041-1723https://doaj.org/article/8274240c07f040b09908063f897c09872016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10971https://doaj.org/toc/2041-1723Synaptotagmin contains tandem Ca2+-binding C2-domains that interact with target membranes to trigger exocytosis. Here, Bai et al. manipulate the relative orientation of these two domains using a synthetic polyproline linker and show that a parallel orientation is most effective for membrane interaction and exocytosis.Hua BaiRenhao XueHuan BaoLeili ZhangArun YethirajQiang CuiEdwin R. ChapmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hua Bai Renhao Xue Huan Bao Leili Zhang Arun Yethiraj Qiang Cui Edwin R. Chapman Different states of synaptotagmin regulate evoked versus spontaneous release
description	Synaptotagmin contains tandem Ca2+-binding C2-domains that interact with target membranes to trigger exocytosis. Here, Bai et al. manipulate the relative orientation of these two domains using a synthetic polyproline linker and show that a parallel orientation is most effective for membrane interaction and exocytosis.
format	article
author	Hua Bai Renhao Xue Huan Bao Leili Zhang Arun Yethiraj Qiang Cui Edwin R. Chapman
author_facet	Hua Bai Renhao Xue Huan Bao Leili Zhang Arun Yethiraj Qiang Cui Edwin R. Chapman
author_sort	Hua Bai
title	Different states of synaptotagmin regulate evoked versus spontaneous release
title_short	Different states of synaptotagmin regulate evoked versus spontaneous release
title_full	Different states of synaptotagmin regulate evoked versus spontaneous release
title_fullStr	Different states of synaptotagmin regulate evoked versus spontaneous release
title_full_unstemmed	Different states of synaptotagmin regulate evoked versus spontaneous release
title_sort	different states of synaptotagmin regulate evoked versus spontaneous release
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8274240c07f040b09908063f897c0987
work_keys_str_mv	AT huabai differentstatesofsynaptotagminregulateevokedversusspontaneousrelease AT renhaoxue differentstatesofsynaptotagminregulateevokedversusspontaneousrelease AT huanbao differentstatesofsynaptotagminregulateevokedversusspontaneousrelease AT leilizhang differentstatesofsynaptotagminregulateevokedversusspontaneousrelease AT arunyethiraj differentstatesofsynaptotagminregulateevokedversusspontaneousrelease AT qiangcui differentstatesofsynaptotagminregulateevokedversusspontaneousrelease AT edwinrchapman differentstatesofsynaptotagminregulateevokedversusspontaneousrelease
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Different states of synaptotagmin regulate evoked versus spontaneous release

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