Caspase-1 initiates apoptosis in the absence of gasdermin D

Caspase-1 initiates apoptosis in the absence of gasdermin D

In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.

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Detalles Bibliográficos
Autores principales: Kohsuke Tsuchiya, Shinsuke Nakajima, Shoko Hosojima, Dinh Thi Nguyen, Tsuyoshi Hattori, Thuong Manh Le, Osamu Hori, Mamunur Rashid Mahib, Yoshifumi Yamaguchi, Masayuki Miura, Takeshi Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, Toshihiko Shiroishi, Takashi Suda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/8277906615eb4c90943b2c2384bee0c7
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Descripción
Sumario:In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.

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