Caspase-1 initiates apoptosis in the absence of gasdermin D

In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.

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Autores principales:	Kohsuke Tsuchiya, Shinsuke Nakajima, Shoko Hosojima, Dinh Thi Nguyen, Tsuyoshi Hattori, Thuong Manh Le, Osamu Hori, Mamunur Rashid Mahib, Yoshifumi Yamaguchi, Masayuki Miura, Takeshi Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, Toshihiko Shiroishi, Takashi Suda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8277906615eb4c90943b2c2384bee0c7
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spelling	oai:doaj.org-article:8277906615eb4c90943b2c2384bee0c72021-12-02T15:36:21ZCaspase-1 initiates apoptosis in the absence of gasdermin D10.1038/s41467-019-09753-22041-1723https://doaj.org/article/8277906615eb4c90943b2c2384bee0c72019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09753-2https://doaj.org/toc/2041-1723In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.Kohsuke TsuchiyaShinsuke NakajimaShoko HosojimaDinh Thi NguyenTsuyoshi HattoriThuong Manh LeOsamu HoriMamunur Rashid MahibYoshifumi YamaguchiMasayuki MiuraTakeshi KinoshitaHiroko KushiyamaMayumi SakuraiToshihiko ShiroishiTakashi SudaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kohsuke Tsuchiya Shinsuke Nakajima Shoko Hosojima Dinh Thi Nguyen Tsuyoshi Hattori Thuong Manh Le Osamu Hori Mamunur Rashid Mahib Yoshifumi Yamaguchi Masayuki Miura Takeshi Kinoshita Hiroko Kushiyama Mayumi Sakurai Toshihiko Shiroishi Takashi Suda Caspase-1 initiates apoptosis in the absence of gasdermin D
description	In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.
format	article
author	Kohsuke Tsuchiya Shinsuke Nakajima Shoko Hosojima Dinh Thi Nguyen Tsuyoshi Hattori Thuong Manh Le Osamu Hori Mamunur Rashid Mahib Yoshifumi Yamaguchi Masayuki Miura Takeshi Kinoshita Hiroko Kushiyama Mayumi Sakurai Toshihiko Shiroishi Takashi Suda
author_facet	Kohsuke Tsuchiya Shinsuke Nakajima Shoko Hosojima Dinh Thi Nguyen Tsuyoshi Hattori Thuong Manh Le Osamu Hori Mamunur Rashid Mahib Yoshifumi Yamaguchi Masayuki Miura Takeshi Kinoshita Hiroko Kushiyama Mayumi Sakurai Toshihiko Shiroishi Takashi Suda
author_sort	Kohsuke Tsuchiya
title	Caspase-1 initiates apoptosis in the absence of gasdermin D
title_short	Caspase-1 initiates apoptosis in the absence of gasdermin D
title_full	Caspase-1 initiates apoptosis in the absence of gasdermin D
title_fullStr	Caspase-1 initiates apoptosis in the absence of gasdermin D
title_full_unstemmed	Caspase-1 initiates apoptosis in the absence of gasdermin D
title_sort	caspase-1 initiates apoptosis in the absence of gasdermin d
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8277906615eb4c90943b2c2384bee0c7
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Caspase-1 initiates apoptosis in the absence of gasdermin D

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