Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders

Mood disorders, including anxiety and depression, are thought to be characterized by disrupted neuronal synapses and altered brain plasticity. The etiology is complex, involving numerous regions of the brain, comprising a multitude of neurotransmitter and neuromodulator systems. Recently, new studie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Woelfle Rebecca, D’Aquila Andrea L., Lovejoy David A.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	addiction anxiety corticotropin-releasing factor neuromodulation secretin peptide family stress synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/82780825e7c8480296fed1c298cbf17d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:82780825e7c8480296fed1c298cbf17d
record_format	dspace
spelling	oai:doaj.org-article:82780825e7c8480296fed1c298cbf17d2021-12-05T14:11:04ZTeneurins, TCAP, and latrophilins: roles in the etiology of mood disorders2081-693610.1515/tnsci-2016-0004https://doaj.org/article/82780825e7c8480296fed1c298cbf17d2016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0004https://doaj.org/toc/2081-6936Mood disorders, including anxiety and depression, are thought to be characterized by disrupted neuronal synapses and altered brain plasticity. The etiology is complex, involving numerous regions of the brain, comprising a multitude of neurotransmitter and neuromodulator systems. Recently, new studies on the teneurins, an evolutionary ancient family of type II transmembrane proteins have been shown to interact with latrophilins (LPHN), a similarly phylogenetically old family of adhesion G protein-coupled receptors (GPCR) forming a transsynaptic adhesion and ligand-receptor pair. Each of the four teneurin proteins contains bioactive sequences termed the teneurin C-terminal associated peptides (TCAP-1–4), which possess a number of neuromodulatory effects. The primary structures of the TCAP are most closely similar to the corticotropin-releasing factor (CRF) family of peptides. CRF has been implicated in a number of diverse mood disorders. Via an association with dystroglycans, synthetic TCAP-1 administration to both embryonic and primary hippocampal cultures induces long-term changes in neuronal structure, specifically increased neurite outgrowth, dendritic branching, and axon growth. Rodent models treated with TCAP-1 show reduced anxiety responses in the elevated plus-maze, openfield test, and acoustic startle test and inhibited CRF-mediated cocaine-seeking behaviour. Thus the teneurin/TCAP-latrophilin interaction may play a major role in the origin, development and treatment of mood disorders.Woelfle RebeccaD’Aquila Andrea L.Lovejoy David A.De Gruyterarticleaddictionanxietycorticotropin-releasing factorneuromodulationsecretin peptide familystresssynaptic plasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 17-23 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	addiction anxiety corticotropin-releasing factor neuromodulation secretin peptide family stress synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	addiction anxiety corticotropin-releasing factor neuromodulation secretin peptide family stress synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Woelfle Rebecca D’Aquila Andrea L. Lovejoy David A. Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders
description	Mood disorders, including anxiety and depression, are thought to be characterized by disrupted neuronal synapses and altered brain plasticity. The etiology is complex, involving numerous regions of the brain, comprising a multitude of neurotransmitter and neuromodulator systems. Recently, new studies on the teneurins, an evolutionary ancient family of type II transmembrane proteins have been shown to interact with latrophilins (LPHN), a similarly phylogenetically old family of adhesion G protein-coupled receptors (GPCR) forming a transsynaptic adhesion and ligand-receptor pair. Each of the four teneurin proteins contains bioactive sequences termed the teneurin C-terminal associated peptides (TCAP-1–4), which possess a number of neuromodulatory effects. The primary structures of the TCAP are most closely similar to the corticotropin-releasing factor (CRF) family of peptides. CRF has been implicated in a number of diverse mood disorders. Via an association with dystroglycans, synthetic TCAP-1 administration to both embryonic and primary hippocampal cultures induces long-term changes in neuronal structure, specifically increased neurite outgrowth, dendritic branching, and axon growth. Rodent models treated with TCAP-1 show reduced anxiety responses in the elevated plus-maze, openfield test, and acoustic startle test and inhibited CRF-mediated cocaine-seeking behaviour. Thus the teneurin/TCAP-latrophilin interaction may play a major role in the origin, development and treatment of mood disorders.
format	article
author	Woelfle Rebecca D’Aquila Andrea L. Lovejoy David A.
author_facet	Woelfle Rebecca D’Aquila Andrea L. Lovejoy David A.
author_sort	Woelfle Rebecca
title	Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders
title_short	Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders
title_full	Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders
title_fullStr	Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders
title_full_unstemmed	Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders
title_sort	teneurins, tcap, and latrophilins: roles in the etiology of mood disorders
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/82780825e7c8480296fed1c298cbf17d
work_keys_str_mv	AT woelflerebecca teneurinstcapandlatrophilinsrolesintheetiologyofmooddisorders AT daquilaandreal teneurinstcapandlatrophilinsrolesintheetiologyofmooddisorders AT lovejoydavida teneurinstcapandlatrophilinsrolesintheetiologyofmooddisorders
_version_	1718371432297136128

Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders

Ejemplares similares