In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice

In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice

Mutations that affect Treg cell function can cause lethal autoimmunity, but whether correcting these mutations can reverse established disease is unclear. Here, the authors correct Treg cell-specific Brg1 mutation in a minor fraction of Treg cells, which supercharges these cells to rescue mice from...

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Autores principales: Yongqin Li, Yuxin Chen, Shaoshuai Mao, Ravinder Kaundal, Zhengyu Jing, Qin Chen, Xinxin Wang, Jing Xia, Dahai Liu, Jianlong Sun, Haopeng Wang, Tian Chi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/827898a24ee34c5db93b756b49a0a191
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spelling oai:doaj.org-article:827898a24ee34c5db93b756b49a0a1912021-12-02T15:56:55ZIn situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice10.1038/s41467-020-15836-22041-1723https://doaj.org/article/827898a24ee34c5db93b756b49a0a1912020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15836-2https://doaj.org/toc/2041-1723Mutations that affect Treg cell function can cause lethal autoimmunity, but whether correcting these mutations can reverse established disease is unclear. Here, the authors correct Treg cell-specific Brg1 mutation in a minor fraction of Treg cells, which supercharges these cells to rescue mice from otherwise fatal IPEX-like autoimmunity.Yongqin LiYuxin ChenShaoshuai MaoRavinder KaundalZhengyu JingQin ChenXinxin WangJing XiaDahai LiuJianlong SunHaopeng WangTian ChiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yongqin Li
Yuxin Chen
Shaoshuai Mao
Ravinder Kaundal
Zhengyu Jing
Qin Chen
Xinxin Wang
Jing Xia
Dahai Liu
Jianlong Sun
Haopeng Wang
Tian Chi
In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice
description Mutations that affect Treg cell function can cause lethal autoimmunity, but whether correcting these mutations can reverse established disease is unclear. Here, the authors correct Treg cell-specific Brg1 mutation in a minor fraction of Treg cells, which supercharges these cells to rescue mice from otherwise fatal IPEX-like autoimmunity.
format article
author Yongqin Li
Yuxin Chen
Shaoshuai Mao
Ravinder Kaundal
Zhengyu Jing
Qin Chen
Xinxin Wang
Jing Xia
Dahai Liu
Jianlong Sun
Haopeng Wang
Tian Chi
author_facet Yongqin Li
Yuxin Chen
Shaoshuai Mao
Ravinder Kaundal
Zhengyu Jing
Qin Chen
Xinxin Wang
Jing Xia
Dahai Liu
Jianlong Sun
Haopeng Wang
Tian Chi
author_sort Yongqin Li
title In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice
title_short In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice
title_full In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice
title_fullStr In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice
title_full_unstemmed In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice
title_sort in situ conversion of defective treg into supertreg cells to treat advanced ipex-like disorders in mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/827898a24ee34c5db93b756b49a0a191
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