In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain

Microglia remodel synapses and engulf apoptotic cells. The molecular program underlying these distinct functions are unclear. Here, the authors identify distinct microglial subsets associated with synaptic vs. neurogenic regions of the developing zebrafish brain.

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Autores principales:	Nicholas J. Silva, Leah C. Dorman, Ilia D. Vainchtein, Nadine C. Horneck, Anna V. Molofsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/827e8387a61f43bfa0b99a363397af48
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spelling	oai:doaj.org-article:827e8387a61f43bfa0b99a363397af482021-12-02T16:57:08ZIn situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain10.1038/s41467-021-26206-x2041-1723https://doaj.org/article/827e8387a61f43bfa0b99a363397af482021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26206-xhttps://doaj.org/toc/2041-1723Microglia remodel synapses and engulf apoptotic cells. The molecular program underlying these distinct functions are unclear. Here, the authors identify distinct microglial subsets associated with synaptic vs. neurogenic regions of the developing zebrafish brain.Nicholas J. SilvaLeah C. DormanIlia D. VainchteinNadine C. HorneckAnna V. MolofskyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas J. Silva Leah C. Dorman Ilia D. Vainchtein Nadine C. Horneck Anna V. Molofsky In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
description	Microglia remodel synapses and engulf apoptotic cells. The molecular program underlying these distinct functions are unclear. Here, the authors identify distinct microglial subsets associated with synaptic vs. neurogenic regions of the developing zebrafish brain.
format	article
author	Nicholas J. Silva Leah C. Dorman Ilia D. Vainchtein Nadine C. Horneck Anna V. Molofsky
author_facet	Nicholas J. Silva Leah C. Dorman Ilia D. Vainchtein Nadine C. Horneck Anna V. Molofsky
author_sort	Nicholas J. Silva
title	In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
title_short	In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
title_full	In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
title_fullStr	In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
title_full_unstemmed	In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
title_sort	in situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/827e8387a61f43bfa0b99a363397af48
work_keys_str_mv	AT nicholasjsilva insituandtranscriptomicidentificationofmicrogliainsynapserichregionsofthedevelopingzebrafishbrain AT leahcdorman insituandtranscriptomicidentificationofmicrogliainsynapserichregionsofthedevelopingzebrafishbrain AT iliadvainchtein insituandtranscriptomicidentificationofmicrogliainsynapserichregionsofthedevelopingzebrafishbrain AT nadinechorneck insituandtranscriptomicidentificationofmicrogliainsynapserichregionsofthedevelopingzebrafishbrain AT annavmolofsky insituandtranscriptomicidentificationofmicrogliainsynapserichregionsofthedevelopingzebrafishbrain
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In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain

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