Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Xiaomin Yi, Fuli Wang, Weijun Qin, Xiaojian Yang, Jianlin Yuan Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China Abstract: Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detec...

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Autores principales:	Yi XM, Wang FL, Qin WJ, Yang XJ, Yuan JL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/827eaeeb79544a87a63dd389b3cea2f7
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spelling	oai:doaj.org-article:827eaeeb79544a87a63dd389b3cea2f72021-12-02T02:42:34ZNear-infrared fluorescent probes in cancer imaging and therapy: an emerging field1178-2013https://doaj.org/article/827eaeeb79544a87a63dd389b3cea2f72014-03-01T00:00:00Zhttp://www.dovepress.com/near-infrared-fluorescent-probes-in-cancer-imaging-and-therapy-an-emer-a16080https://doaj.org/toc/1178-2013 Xiaomin Yi, Fuli Wang, Weijun Qin, Xiaojian Yang, Jianlin Yuan Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China Abstract: Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized. Keywords: near infrared dyes, nanoparticles, imaging, cancer targeting, cancer therapyYi XMWang FLQin WJYang XJYuan JLDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1347-1365 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yi XM Wang FL Qin WJ Yang XJ Yuan JL Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field
description	Xiaomin Yi, Fuli Wang, Weijun Qin, Xiaojian Yang, Jianlin Yuan Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China Abstract: Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized. Keywords: near infrared dyes, nanoparticles, imaging, cancer targeting, cancer therapy
format	article
author	Yi XM Wang FL Qin WJ Yang XJ Yuan JL
author_facet	Yi XM Wang FL Qin WJ Yang XJ Yuan JL
author_sort	Yi XM
title	Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field
title_short	Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field
title_full	Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field
title_fullStr	Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field
title_full_unstemmed	Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field
title_sort	near-infrared fluorescent probes in cancer imaging and therapy: an emerging field
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/827eaeeb79544a87a63dd389b3cea2f7
work_keys_str_mv	AT yixm nearinfraredfluorescentprobesincancerimagingandtherapyanemergingfield AT wangfl nearinfraredfluorescentprobesincancerimagingandtherapyanemergingfield AT qinwj nearinfraredfluorescentprobesincancerimagingandtherapyanemergingfield AT yangxj nearinfraredfluorescentprobesincancerimagingandtherapyanemergingfield AT yuanjl nearinfraredfluorescentprobesincancerimagingandtherapyanemergingfield
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Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

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