Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR
Catherine M Kuecker, Eva M Vivian Pharmacy Practice Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA Purpose: The purpose of this review article is to provide guidance to health care providers regarding the use of dapagliflozin–metformin XR (extended release...
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Dove Medical Press
2016
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oai:doaj.org-article:827fb93c84134002b6a1b48ce781d1102021-12-02T04:38:33ZPatient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR1178-7007https://doaj.org/article/827fb93c84134002b6a1b48ce781d1102016-02-01T00:00:00Zhttps://www.dovepress.com/patient-considerations-in-type-2-diabetes-ndash-role-of-combination-da-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Catherine M Kuecker, Eva M Vivian Pharmacy Practice Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA Purpose: The purpose of this review article is to provide guidance to health care providers regarding the use of dapagliflozin–metformin XR (extended release) as a therapeutic option for the treatment of patients with type 2 diabetes mellitus (T2DM). Methods: The PubMed database was searched through August 2015 to identify clinical trials and meta-analyses evaluating the use of the sodium–glucose cotransporter type 2 inhibitor dapagliflozin administered as monotherapy or in combination with metformin. Results: Fourteen studies were included for this review, six of which evaluated dapagliflozin in combination with metformin, one of which evaluated dapagliflozin monotherapy, and four of which evaluated dapagliflozin as an add-on therapy to other antidiabetic agents. The combination of dapagliflozin and metformin resulted in an A1C decrease of up to 2%, weight loss of 2–3 kg, and modest systolic blood pressure decrease of 3–5 mmHg. However, long-term effects on cancer and cardiovascular health are still being investigated. Providing patients with a fixed-dose combination therapy such as dapagliflozin-metformin XR can increase medication adherence and patient satisfaction, and improve glycemic control. Dapagliflozin–metformin XR is ideal because it can be administered orally once a day, is associated with a low risk of hypoglycemia, and provides the added benefit of weight reduction and modest blood pressure lowering. Conclusion: The unique combined mechanism of action and favorable efficacy and safety profile of dapagliflozin–metformin XR support consideration of this fixed-dose combination as a treatment option for patients with T2DM. Keywords: fixed-dose combination therapy, metformin, SGLT2 inhibitorKuecker CMVivian EMDove Medical Pressarticletype 2 diabetesfixed dose combination therapydapagliflozin-metformin XRmetforminSGLT2 inhibitorSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 25-35 (2016) |
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type 2 diabetes fixed dose combination therapy dapagliflozin-metformin XR metformin SGLT2 inhibitor Specialties of internal medicine RC581-951 |
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type 2 diabetes fixed dose combination therapy dapagliflozin-metformin XR metformin SGLT2 inhibitor Specialties of internal medicine RC581-951 Kuecker CM Vivian EM Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR |
| description |
Catherine M Kuecker, Eva M Vivian Pharmacy Practice Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA Purpose: The purpose of this review article is to provide guidance to health care providers regarding the use of dapagliflozin–metformin XR (extended release) as a therapeutic option for the treatment of patients with type 2 diabetes mellitus (T2DM). Methods: The PubMed database was searched through August 2015 to identify clinical trials and meta-analyses evaluating the use of the sodium–glucose cotransporter type 2 inhibitor dapagliflozin administered as monotherapy or in combination with metformin. Results: Fourteen studies were included for this review, six of which evaluated dapagliflozin in combination with metformin, one of which evaluated dapagliflozin monotherapy, and four of which evaluated dapagliflozin as an add-on therapy to other antidiabetic agents. The combination of dapagliflozin and metformin resulted in an A1C decrease of up to 2%, weight loss of 2–3 kg, and modest systolic blood pressure decrease of 3–5 mmHg. However, long-term effects on cancer and cardiovascular health are still being investigated. Providing patients with a fixed-dose combination therapy such as dapagliflozin-metformin XR can increase medication adherence and patient satisfaction, and improve glycemic control. Dapagliflozin–metformin XR is ideal because it can be administered orally once a day, is associated with a low risk of hypoglycemia, and provides the added benefit of weight reduction and modest blood pressure lowering. Conclusion: The unique combined mechanism of action and favorable efficacy and safety profile of dapagliflozin–metformin XR support consideration of this fixed-dose combination as a treatment option for patients with T2DM. Keywords: fixed-dose combination therapy, metformin, SGLT2 inhibitor |
| format |
article |
| author |
Kuecker CM Vivian EM |
| author_facet |
Kuecker CM Vivian EM |
| author_sort |
Kuecker CM |
| title |
Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR |
| title_short |
Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR |
| title_full |
Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR |
| title_fullStr |
Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR |
| title_full_unstemmed |
Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR |
| title_sort |
patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin xr |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/827fb93c84134002b6a1b48ce781d110 |
| work_keys_str_mv |
AT kueckercm patientconsiderationsintype2diabetesndashroleofcombinationdapagliflozinndashmetforminxr AT vivianem patientconsiderationsintype2diabetesndashroleofcombinationdapagliflozinndashmetforminxr |
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