ZNF768 links oncogenic RAS to cellular senescence
KEY FINDINGS ZNF768 is phosphorylated and degraded upon RAS activation ZNF768 depletion impairs proliferation and causes cellular senescence ZNF768 binds and represses p53 and its overexpression suffices to bypass senescence Elevated ZNF768 levels in human tumors may serve to avoid cellular senescen...
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Nature Portfolio
2021
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oai:doaj.org-article:8280dad19e4949b787cc212a7dfd30682021-12-02T17:08:39ZZNF768 links oncogenic RAS to cellular senescence10.1038/s41467-021-24932-w2041-1723https://doaj.org/article/8280dad19e4949b787cc212a7dfd30682021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24932-whttps://doaj.org/toc/2041-1723KEY FINDINGS ZNF768 is phosphorylated and degraded upon RAS activation ZNF768 depletion impairs proliferation and causes cellular senescence ZNF768 binds and represses p53 and its overexpression suffices to bypass senescence Elevated ZNF768 levels in human tumors may serve to avoid cellular senescence and support proliferationRomain VillotAudrey PoirierInan BakanKarine BoulayErlinda FernándezRomain DevillersLuciano Gama-BragaLaura TribouillardAndréanne GagnéÉma DuchesneDanielle CaronJean-Sébastien BérubéJean-Christophe BérubéYan CoulombeMichèle OrainYves GélinasStéphane GobeilYohan BosséJean-Yves MassonSabine EloweSteve BilodeauVenkata ManemPhilippe JoubertFrédérick A. MalletteMathieu LaplanteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Romain Villot Audrey Poirier Inan Bakan Karine Boulay Erlinda Fernández Romain Devillers Luciano Gama-Braga Laura Tribouillard Andréanne Gagné Éma Duchesne Danielle Caron Jean-Sébastien Bérubé Jean-Christophe Bérubé Yan Coulombe Michèle Orain Yves Gélinas Stéphane Gobeil Yohan Bossé Jean-Yves Masson Sabine Elowe Steve Bilodeau Venkata Manem Philippe Joubert Frédérick A. Mallette Mathieu Laplante ZNF768 links oncogenic RAS to cellular senescence |
| description |
KEY FINDINGS ZNF768 is phosphorylated and degraded upon RAS activation ZNF768 depletion impairs proliferation and causes cellular senescence ZNF768 binds and represses p53 and its overexpression suffices to bypass senescence Elevated ZNF768 levels in human tumors may serve to avoid cellular senescence and support proliferation |
| format |
article |
| author |
Romain Villot Audrey Poirier Inan Bakan Karine Boulay Erlinda Fernández Romain Devillers Luciano Gama-Braga Laura Tribouillard Andréanne Gagné Éma Duchesne Danielle Caron Jean-Sébastien Bérubé Jean-Christophe Bérubé Yan Coulombe Michèle Orain Yves Gélinas Stéphane Gobeil Yohan Bossé Jean-Yves Masson Sabine Elowe Steve Bilodeau Venkata Manem Philippe Joubert Frédérick A. Mallette Mathieu Laplante |
| author_facet |
Romain Villot Audrey Poirier Inan Bakan Karine Boulay Erlinda Fernández Romain Devillers Luciano Gama-Braga Laura Tribouillard Andréanne Gagné Éma Duchesne Danielle Caron Jean-Sébastien Bérubé Jean-Christophe Bérubé Yan Coulombe Michèle Orain Yves Gélinas Stéphane Gobeil Yohan Bossé Jean-Yves Masson Sabine Elowe Steve Bilodeau Venkata Manem Philippe Joubert Frédérick A. Mallette Mathieu Laplante |
| author_sort |
Romain Villot |
| title |
ZNF768 links oncogenic RAS to cellular senescence |
| title_short |
ZNF768 links oncogenic RAS to cellular senescence |
| title_full |
ZNF768 links oncogenic RAS to cellular senescence |
| title_fullStr |
ZNF768 links oncogenic RAS to cellular senescence |
| title_full_unstemmed |
ZNF768 links oncogenic RAS to cellular senescence |
| title_sort |
znf768 links oncogenic ras to cellular senescence |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068 |
| work_keys_str_mv |
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1718381508269441024 |