Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.

<h4>Background</h4>Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disease in which danger-associated molecular patterns (DAMPs)-mediated inflammasome activation seems to be involved in the disease pathogenesis. Cold-inducible RNA-binding protein (CIRP) belongs to...

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Autores principales: Yuya Fujita, Toru Yago, Tomoyuki Asano, Haruki Matsumoto, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro-Furuya, Eiji Suzuki, Hiroshi Watanabe, Atsushi Kawakami, Kiyoshi Migita
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:82838577759b43a39699a721c0d19c742021-12-02T20:18:40ZClinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.1932-620310.1371/journal.pone.0255493https://doaj.org/article/82838577759b43a39699a721c0d19c742021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255493https://doaj.org/toc/1932-6203<h4>Background</h4>Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disease in which danger-associated molecular patterns (DAMPs)-mediated inflammasome activation seems to be involved in the disease pathogenesis. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond to cellular stress and has been identified as a DAMP that triggers the inflammatory response. The aim of this study is to investigate the clinical significance of serum CIRP levels in AOSD.<h4>Methods</h4>Serum samples were obtained from 44 patients with active AOSD or 50 patients with rheumatoid arthritis (RA), 20 patients with systemic lupus erythematosus (SLE), and 15 healthy control patients (HCs). Serum levels of CIRP and IL-18 were determined using enzyme-linked immunosorbent assay. Results were compared among AOSD patients, RA patients, SLE patients and HCs. Results were also analyzed according to the clinical features of AOSD.<h4>Results</h4>Serum CIRP levels were significantly higher in AOSD patients compared with RA patients (median: 9.6 ng/mL, IQR [5.7-14.4] versus 3.2 ng/mL, IQR [1.9-3.8]; p < 0.001) and with HCs (2.8 ng/mL, [IQR; 1.4-4.9], p < 0.001). There was a significant positive correlation between serum CIRP levels and AOSD disease activity score (Pouchot's score r = 0.45, p = 0.003) as well as between AOSD-specific biomarkers ferritin and IL-18. However, there was no significant difference in the serum CIRP levels among AOSD patients with three different disease phenotypes.<h4>Conclusions</h4>These results suggest that CIRP may play a significant role in the pathophysiology of AOSD and could be a potential biomarker for monitoring the disease activity of AOSD.Yuya FujitaToru YagoTomoyuki AsanoHaruki MatsumotoNaoki MatsuokaJumpei TemmokuShuzo SatoMakiko Yashiro-FuruyaEiji SuzukiHiroshi WatanabeAtsushi KawakamiKiyoshi MigitaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255493 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yuya Fujita
Toru Yago
Tomoyuki Asano
Haruki Matsumoto
Naoki Matsuoka
Jumpei Temmoku
Shuzo Sato
Makiko Yashiro-Furuya
Eiji Suzuki
Hiroshi Watanabe
Atsushi Kawakami
Kiyoshi Migita
Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
description <h4>Background</h4>Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disease in which danger-associated molecular patterns (DAMPs)-mediated inflammasome activation seems to be involved in the disease pathogenesis. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond to cellular stress and has been identified as a DAMP that triggers the inflammatory response. The aim of this study is to investigate the clinical significance of serum CIRP levels in AOSD.<h4>Methods</h4>Serum samples were obtained from 44 patients with active AOSD or 50 patients with rheumatoid arthritis (RA), 20 patients with systemic lupus erythematosus (SLE), and 15 healthy control patients (HCs). Serum levels of CIRP and IL-18 were determined using enzyme-linked immunosorbent assay. Results were compared among AOSD patients, RA patients, SLE patients and HCs. Results were also analyzed according to the clinical features of AOSD.<h4>Results</h4>Serum CIRP levels were significantly higher in AOSD patients compared with RA patients (median: 9.6 ng/mL, IQR [5.7-14.4] versus 3.2 ng/mL, IQR [1.9-3.8]; p < 0.001) and with HCs (2.8 ng/mL, [IQR; 1.4-4.9], p < 0.001). There was a significant positive correlation between serum CIRP levels and AOSD disease activity score (Pouchot's score r = 0.45, p = 0.003) as well as between AOSD-specific biomarkers ferritin and IL-18. However, there was no significant difference in the serum CIRP levels among AOSD patients with three different disease phenotypes.<h4>Conclusions</h4>These results suggest that CIRP may play a significant role in the pathophysiology of AOSD and could be a potential biomarker for monitoring the disease activity of AOSD.
format article
author Yuya Fujita
Toru Yago
Tomoyuki Asano
Haruki Matsumoto
Naoki Matsuoka
Jumpei Temmoku
Shuzo Sato
Makiko Yashiro-Furuya
Eiji Suzuki
Hiroshi Watanabe
Atsushi Kawakami
Kiyoshi Migita
author_facet Yuya Fujita
Toru Yago
Tomoyuki Asano
Haruki Matsumoto
Naoki Matsuoka
Jumpei Temmoku
Shuzo Sato
Makiko Yashiro-Furuya
Eiji Suzuki
Hiroshi Watanabe
Atsushi Kawakami
Kiyoshi Migita
author_sort Yuya Fujita
title Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
title_short Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
title_full Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
title_fullStr Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
title_full_unstemmed Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
title_sort clinical relevance for circulating cold-inducible rna-binding protein (cirp) in patients with adult-onset still's disease.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/82838577759b43a39699a721c0d19c74
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