The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

Hop, also known as Stip1 or Sti1, facilitates substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Characterization of proteostasis-related pathways in STIP1 knock-out cell lines reveals that in eukaryotes Stip1 modulates the balance between protein folding and degradation.

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Autores principales:	Kaushik Bhattacharya, Lorenz Weidenauer, Tania Morán Luengo, Ellis C. Pieters, Pablo C. Echeverría, Lilia Bernasconi, Diana Wider, Yashar Sadian, Margreet B. Koopman, Matthieu Villemin, Christoph Bauer, Stefan G. D. Rüdiger, Manfredo Quadroni, Didier Picard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82875625c72b4d9c8c7eaaf0131c13bc
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spelling	oai:doaj.org-article:82875625c72b4d9c8c7eaaf0131c13bc2021-12-02T10:48:29ZThe Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation10.1038/s41467-020-19783-w2041-1723https://doaj.org/article/82875625c72b4d9c8c7eaaf0131c13bc2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19783-whttps://doaj.org/toc/2041-1723Hop, also known as Stip1 or Sti1, facilitates substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Characterization of proteostasis-related pathways in STIP1 knock-out cell lines reveals that in eukaryotes Stip1 modulates the balance between protein folding and degradation.Kaushik BhattacharyaLorenz WeidenauerTania Morán LuengoEllis C. PietersPablo C. EcheverríaLilia BernasconiDiana WiderYashar SadianMargreet B. KoopmanMatthieu VilleminChristoph BauerStefan G. D. RüdigerManfredo QuadroniDidier PicardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaushik Bhattacharya Lorenz Weidenauer Tania Morán Luengo Ellis C. Pieters Pablo C. Echeverría Lilia Bernasconi Diana Wider Yashar Sadian Margreet B. Koopman Matthieu Villemin Christoph Bauer Stefan G. D. Rüdiger Manfredo Quadroni Didier Picard The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
description	Hop, also known as Stip1 or Sti1, facilitates substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Characterization of proteostasis-related pathways in STIP1 knock-out cell lines reveals that in eukaryotes Stip1 modulates the balance between protein folding and degradation.
format	article
author	Kaushik Bhattacharya Lorenz Weidenauer Tania Morán Luengo Ellis C. Pieters Pablo C. Echeverría Lilia Bernasconi Diana Wider Yashar Sadian Margreet B. Koopman Matthieu Villemin Christoph Bauer Stefan G. D. Rüdiger Manfredo Quadroni Didier Picard
author_facet	Kaushik Bhattacharya Lorenz Weidenauer Tania Morán Luengo Ellis C. Pieters Pablo C. Echeverría Lilia Bernasconi Diana Wider Yashar Sadian Margreet B. Koopman Matthieu Villemin Christoph Bauer Stefan G. D. Rüdiger Manfredo Quadroni Didier Picard
author_sort	Kaushik Bhattacharya
title	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
title_short	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
title_full	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
title_fullStr	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
title_full_unstemmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
title_sort	hsp70-hsp90 co-chaperone hop/stip1 shifts the proteostatic balance from folding towards degradation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/82875625c72b4d9c8c7eaaf0131c13bc
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The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

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