Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.

<h4>Objective</h4>Patients who undergo Fontan surgery for complex cardiac anomalies are prone to developing liver and gastrointestinal complications. In particular, gastroesophageal varices (GEVs) can occur, but their prevalence is unknown. We aimed to elucidate the occurrence of GEVs an...

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Autores principales:	Yoshiharu Isoura, Akira Yamamoto, Yuki Cho, Eiji Ehara, Atsushi Jogo, Tsugutoshi Suzuki, Yuga Amano-Teranishi, Kiyohide Kioka, Takashi Hamazaki, Yosuke Murakami, Daisuke Tokuhara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8289ac4b66774067b91b0307f0c20700
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spelling	oai:doaj.org-article:8289ac4b66774067b91b0307f0c207002021-12-02T20:17:13ZPlatelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.1932-620310.1371/journal.pone.0257441https://doaj.org/article/8289ac4b66774067b91b0307f0c207002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257441https://doaj.org/toc/1932-6203<h4>Objective</h4>Patients who undergo Fontan surgery for complex cardiac anomalies are prone to developing liver and gastrointestinal complications. In particular, gastroesophageal varices (GEVs) can occur, but their prevalence is unknown. We aimed to elucidate the occurrence of GEVs and the predicting parameters of GEVs in these patients.<h4>Materials and methods</h4>Twenty-seven patients (median age, 14.8 years; median time since surgery, 12.9 years) who had undergone the Fontan surgery and were examined by abdominal dynamic computed tomography (CT) for the routine follow-up were included in the study. Radiological findings including GEVs and extraintestinal complications were retrospectively evaluated by experienced radiologists in a blinded manner. Relationships between blood-biochemical and demographic parameters and the presence of GEVs were statistically analyzed.<h4>Results</h4>Dynamic CT revealed gastric varices (n = 3, 11.1%), esophageal varices (n = 1, 3.7%), and gastrorenal shunts (n = 5, 18.5%). All patients with gastric varices had gastrorenal shunts. All gastric varices were endoscopically confirmed as being isolated and enlarged, with indications for preventive interventional therapy. A platelet count lower than 119 × 109 /L was identified as a predictor of GEV (area under the receiver operating curve, 0.946; sensitivity, 100%; and specificity, 87%).<h4>Conclusions</h4>GEVs are important complications that should not be ignored in patients who have undergone a Fontan procedure. Platelet counts lower than 119 × 109 /L may help to prompt patient screening by using abdominal dynamic CT to identify GEVs and their draining collateral veins in these patients.Yoshiharu IsouraAkira YamamotoYuki ChoEiji EharaAtsushi JogoTsugutoshi SuzukiYuga Amano-TeranishiKiyohide KiokaTakashi HamazakiYosuke MurakamiDaisuke TokuharaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257441 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshiharu Isoura Akira Yamamoto Yuki Cho Eiji Ehara Atsushi Jogo Tsugutoshi Suzuki Yuga Amano-Teranishi Kiyohide Kioka Takashi Hamazaki Yosuke Murakami Daisuke Tokuhara Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.
description	<h4>Objective</h4>Patients who undergo Fontan surgery for complex cardiac anomalies are prone to developing liver and gastrointestinal complications. In particular, gastroesophageal varices (GEVs) can occur, but their prevalence is unknown. We aimed to elucidate the occurrence of GEVs and the predicting parameters of GEVs in these patients.<h4>Materials and methods</h4>Twenty-seven patients (median age, 14.8 years; median time since surgery, 12.9 years) who had undergone the Fontan surgery and were examined by abdominal dynamic computed tomography (CT) for the routine follow-up were included in the study. Radiological findings including GEVs and extraintestinal complications were retrospectively evaluated by experienced radiologists in a blinded manner. Relationships between blood-biochemical and demographic parameters and the presence of GEVs were statistically analyzed.<h4>Results</h4>Dynamic CT revealed gastric varices (n = 3, 11.1%), esophageal varices (n = 1, 3.7%), and gastrorenal shunts (n = 5, 18.5%). All patients with gastric varices had gastrorenal shunts. All gastric varices were endoscopically confirmed as being isolated and enlarged, with indications for preventive interventional therapy. A platelet count lower than 119 × 109 /L was identified as a predictor of GEV (area under the receiver operating curve, 0.946; sensitivity, 100%; and specificity, 87%).<h4>Conclusions</h4>GEVs are important complications that should not be ignored in patients who have undergone a Fontan procedure. Platelet counts lower than 119 × 109 /L may help to prompt patient screening by using abdominal dynamic CT to identify GEVs and their draining collateral veins in these patients.
format	article
author	Yoshiharu Isoura Akira Yamamoto Yuki Cho Eiji Ehara Atsushi Jogo Tsugutoshi Suzuki Yuga Amano-Teranishi Kiyohide Kioka Takashi Hamazaki Yosuke Murakami Daisuke Tokuhara
author_facet	Yoshiharu Isoura Akira Yamamoto Yuki Cho Eiji Ehara Atsushi Jogo Tsugutoshi Suzuki Yuga Amano-Teranishi Kiyohide Kioka Takashi Hamazaki Yosuke Murakami Daisuke Tokuhara
author_sort	Yoshiharu Isoura
title	Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.
title_short	Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.
title_full	Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.
title_fullStr	Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.
title_full_unstemmed	Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.
title_sort	platelet count and abdominal dynamic ct are useful in predicting and screening for gastroesophageal varices after fontan surgery.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8289ac4b66774067b91b0307f0c20700
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Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.

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