RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization

Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing is also induced by IFN-1 exposure in tumor-associat...

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Autores principales:	Emad Y. Alqassim, Shraddha Sharma, A. N. M. Nazmul H. Khan, Tiffany R. Emmons, Eduardo Cortes Gomez, Abdulrahman Alahmari, Kelly L. Singel, Jaron Mark, Bruce A. Davidson, A. J. Robert McGray, Qian Liu, Brian D. Lichty, Kirsten B. Moysich, Jianmin Wang, Kunle Odunsi, Brahm H. Segal, Bora E. Baysal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8289df36f80e4288872e7c05d2e770f3
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spelling	oai:doaj.org-article:8289df36f80e4288872e7c05d2e770f32021-12-02T11:50:30ZRNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization10.1038/s42003-020-01620-x2399-3642https://doaj.org/article/8289df36f80e4288872e7c05d2e770f32021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01620-xhttps://doaj.org/toc/2399-3642Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing is also induced by IFN-1 exposure in tumor-associated macrophages isolated from ovarian cancer-related ascites fluid, pointing to a wide role for APOBEC3A in macrophages.Emad Y. AlqassimShraddha SharmaA. N. M. Nazmul H. KhanTiffany R. EmmonsEduardo Cortes GomezAbdulrahman AlahmariKelly L. SingelJaron MarkBruce A. DavidsonA. J. Robert McGrayQian LiuBrian D. LichtyKirsten B. MoysichJianmin WangKunle OdunsiBrahm H. SegalBora E. BaysalNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Emad Y. Alqassim Shraddha Sharma A. N. M. Nazmul H. Khan Tiffany R. Emmons Eduardo Cortes Gomez Abdulrahman Alahmari Kelly L. Singel Jaron Mark Bruce A. Davidson A. J. Robert McGray Qian Liu Brian D. Lichty Kirsten B. Moysich Jianmin Wang Kunle Odunsi Brahm H. Segal Bora E. Baysal RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
description	Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing is also induced by IFN-1 exposure in tumor-associated macrophages isolated from ovarian cancer-related ascites fluid, pointing to a wide role for APOBEC3A in macrophages.
format	article
author	Emad Y. Alqassim Shraddha Sharma A. N. M. Nazmul H. Khan Tiffany R. Emmons Eduardo Cortes Gomez Abdulrahman Alahmari Kelly L. Singel Jaron Mark Bruce A. Davidson A. J. Robert McGray Qian Liu Brian D. Lichty Kirsten B. Moysich Jianmin Wang Kunle Odunsi Brahm H. Segal Bora E. Baysal
author_facet	Emad Y. Alqassim Shraddha Sharma A. N. M. Nazmul H. Khan Tiffany R. Emmons Eduardo Cortes Gomez Abdulrahman Alahmari Kelly L. Singel Jaron Mark Bruce A. Davidson A. J. Robert McGray Qian Liu Brian D. Lichty Kirsten B. Moysich Jianmin Wang Kunle Odunsi Brahm H. Segal Bora E. Baysal
author_sort	Emad Y. Alqassim
title	RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
title_short	RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
title_full	RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
title_fullStr	RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
title_full_unstemmed	RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
title_sort	rna editing enzyme apobec3a promotes pro-inflammatory m1 macrophage polarization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8289df36f80e4288872e7c05d2e770f3
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RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization

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