RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization

RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization

Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing is also induced by IFN-1 exposure in tumor-associat...

Full description

Saved in:
Bibliographic Details
Main Authors: Emad Y. Alqassim, Shraddha Sharma, A. N. M. Nazmul H. Khan, Tiffany R. Emmons, Eduardo Cortes Gomez, Abdulrahman Alahmari, Kelly L. Singel, Jaron Mark, Bruce A. Davidson, A. J. Robert McGray, Qian Liu, Brian D. Lichty, Kirsten B. Moysich, Jianmin Wang, Kunle Odunsi, Brahm H. Segal, Bora E. Baysal
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/8289df36f80e4288872e7c05d2e770f3
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/8289df36f80e4288872e7c05d2e770f3

Similar Items