A modular synthesis of tetracyclic meroterpenoid antibiotics

A modular synthesis of tetracyclic meroterpenoid antibiotics

Polycyclic meroterpenoids show a wide range of biological activities. Here, the authors report a modular approach to synthesize a number of natural and non-natural tetracyclic meroterpenoids, which display antibiotic activity against methicillin-resistant Staphylococcus aureus.

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Autores principales: Raphael Wildermuth, Klaus Speck, Franz-Lucas Haut, Peter Mayer, Bianka Karge, Mark Brönstrup, Thomas Magauer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/828a990bf84a4931874447ef9ccb3ec3
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spelling oai:doaj.org-article:828a990bf84a4931874447ef9ccb3ec32021-12-02T14:42:05ZA modular synthesis of tetracyclic meroterpenoid antibiotics10.1038/s41467-017-02061-72041-1723https://doaj.org/article/828a990bf84a4931874447ef9ccb3ec32017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02061-7https://doaj.org/toc/2041-1723Polycyclic meroterpenoids show a wide range of biological activities. Here, the authors report a modular approach to synthesize a number of natural and non-natural tetracyclic meroterpenoids, which display antibiotic activity against methicillin-resistant Staphylococcus aureus.Raphael WildermuthKlaus SpeckFranz-Lucas HautPeter MayerBianka KargeMark BrönstrupThomas MagauerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Raphael Wildermuth
Klaus Speck
Franz-Lucas Haut
Peter Mayer
Bianka Karge
Mark Brönstrup
Thomas Magauer
A modular synthesis of tetracyclic meroterpenoid antibiotics
description Polycyclic meroterpenoids show a wide range of biological activities. Here, the authors report a modular approach to synthesize a number of natural and non-natural tetracyclic meroterpenoids, which display antibiotic activity against methicillin-resistant Staphylococcus aureus.
format article
author Raphael Wildermuth
Klaus Speck
Franz-Lucas Haut
Peter Mayer
Bianka Karge
Mark Brönstrup
Thomas Magauer
author_facet Raphael Wildermuth
Klaus Speck
Franz-Lucas Haut
Peter Mayer
Bianka Karge
Mark Brönstrup
Thomas Magauer
author_sort Raphael Wildermuth
title A modular synthesis of tetracyclic meroterpenoid antibiotics
title_short A modular synthesis of tetracyclic meroterpenoid antibiotics
title_full A modular synthesis of tetracyclic meroterpenoid antibiotics
title_fullStr A modular synthesis of tetracyclic meroterpenoid antibiotics
title_full_unstemmed A modular synthesis of tetracyclic meroterpenoid antibiotics
title_sort modular synthesis of tetracyclic meroterpenoid antibiotics
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/828a990bf84a4931874447ef9ccb3ec3
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AT klausspeck amodularsynthesisoftetracyclicmeroterpenoidantibiotics
AT franzlucashaut amodularsynthesisoftetracyclicmeroterpenoidantibiotics
AT petermayer amodularsynthesisoftetracyclicmeroterpenoidantibiotics
AT biankakarge amodularsynthesisoftetracyclicmeroterpenoidantibiotics
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AT biankakarge modularsynthesisoftetracyclicmeroterpenoidantibiotics
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