Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study

Abstract The association of salivary α-amylase activity (SAA) activity or low copy number of its coding gene AMY1 with diabetes remains controversial. We aimed to reinvestigate the association of these factors with diabetes in Qatar, where diabetes prevalence is about 16%. We obtained cross-sectiona...

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Autores principales:	Neyla S. Al-Akl, Richard Ian Thompson, Abdelilah Arredouani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/828bca45b5a64158b72ba7d16f8d91a9
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spelling	oai:doaj.org-article:828bca45b5a64158b72ba7d16f8d91a92021-12-02T15:02:23ZReduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study10.1038/s41598-021-90977-y2045-2322https://doaj.org/article/828bca45b5a64158b72ba7d16f8d91a92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90977-yhttps://doaj.org/toc/2045-2322Abstract The association of salivary α-amylase activity (SAA) activity or low copy number of its coding gene AMY1 with diabetes remains controversial. We aimed to reinvestigate the association of these factors with diabetes in Qatar, where diabetes prevalence is about 16%. We obtained cross-sectional data of 929 Qataris (age > 18 years) from the Qatar Biobank. We estimated AMY1 copy number variants (CNV) from whole-genome data, and quantified the SAA activity in plasma (pSAA). We used adjusted logistic regression to examine the association between pSAA activity or AMY1 CNV and diabetes odds. We found a significant association between high pSAA activity, but not AMY1 CNV, and reduced odds of diabetes in Qatari women. The OR per pSAA activity unit was 0.95 [95% CI 0.92, 0.98] (p = 0.002) (pSAA activity range: 4.7 U/L to 65 U/L) in women. The association is driven largely by the highest levels of pSAA activity. The probability of having diabetes was significantly lower in the fifth pSAA activity quintile relative to the first (0.21 ± 0.03 (Q1) versus 0.82 ± 0.02 (Q5)), resulting in significantly reduced diabetes prevalence in Q5 in women. Our study indicates a beneficial effect of high pSAA activity, but not AMY1 CN, on diabetes odds in Qatari women, and suggests pSAA activity levels as a potential marker to predict future diabetes in Qatari women.Neyla S. Al-AklRichard Ian ThompsonAbdelilah ArredouaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Neyla S. Al-Akl Richard Ian Thompson Abdelilah Arredouani Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
description	Abstract The association of salivary α-amylase activity (SAA) activity or low copy number of its coding gene AMY1 with diabetes remains controversial. We aimed to reinvestigate the association of these factors with diabetes in Qatar, where diabetes prevalence is about 16%. We obtained cross-sectional data of 929 Qataris (age > 18 years) from the Qatar Biobank. We estimated AMY1 copy number variants (CNV) from whole-genome data, and quantified the SAA activity in plasma (pSAA). We used adjusted logistic regression to examine the association between pSAA activity or AMY1 CNV and diabetes odds. We found a significant association between high pSAA activity, but not AMY1 CNV, and reduced odds of diabetes in Qatari women. The OR per pSAA activity unit was 0.95 [95% CI 0.92, 0.98] (p = 0.002) (pSAA activity range: 4.7 U/L to 65 U/L) in women. The association is driven largely by the highest levels of pSAA activity. The probability of having diabetes was significantly lower in the fifth pSAA activity quintile relative to the first (0.21 ± 0.03 (Q1) versus 0.82 ± 0.02 (Q5)), resulting in significantly reduced diabetes prevalence in Q5 in women. Our study indicates a beneficial effect of high pSAA activity, but not AMY1 CN, on diabetes odds in Qatari women, and suggests pSAA activity levels as a potential marker to predict future diabetes in Qatari women.
format	article
author	Neyla S. Al-Akl Richard Ian Thompson Abdelilah Arredouani
author_facet	Neyla S. Al-Akl Richard Ian Thompson Abdelilah Arredouani
author_sort	Neyla S. Al-Akl
title	Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
title_short	Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
title_full	Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
title_fullStr	Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
title_full_unstemmed	Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
title_sort	reduced odds of diabetes associated with high plasma salivary α-amylase activity in qatari women: a cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/828bca45b5a64158b72ba7d16f8d91a9
work_keys_str_mv	AT neylasalakl reducedoddsofdiabetesassociatedwithhighplasmasalivaryaamylaseactivityinqatariwomenacrosssectionalstudy AT richardianthompson reducedoddsofdiabetesassociatedwithhighplasmasalivaryaamylaseactivityinqatariwomenacrosssectionalstudy AT abdelilaharredouani reducedoddsofdiabetesassociatedwithhighplasmasalivaryaamylaseactivityinqatariwomenacrosssectionalstudy
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Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study

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