Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
Abstract The association of salivary α-amylase activity (SAA) activity or low copy number of its coding gene AMY1 with diabetes remains controversial. We aimed to reinvestigate the association of these factors with diabetes in Qatar, where diabetes prevalence is about 16%. We obtained cross-sectiona...
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Nature Portfolio
2021
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oai:doaj.org-article:828bca45b5a64158b72ba7d16f8d91a92021-12-02T15:02:23ZReduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study10.1038/s41598-021-90977-y2045-2322https://doaj.org/article/828bca45b5a64158b72ba7d16f8d91a92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90977-yhttps://doaj.org/toc/2045-2322Abstract The association of salivary α-amylase activity (SAA) activity or low copy number of its coding gene AMY1 with diabetes remains controversial. We aimed to reinvestigate the association of these factors with diabetes in Qatar, where diabetes prevalence is about 16%. We obtained cross-sectional data of 929 Qataris (age > 18 years) from the Qatar Biobank. We estimated AMY1 copy number variants (CNV) from whole-genome data, and quantified the SAA activity in plasma (pSAA). We used adjusted logistic regression to examine the association between pSAA activity or AMY1 CNV and diabetes odds. We found a significant association between high pSAA activity, but not AMY1 CNV, and reduced odds of diabetes in Qatari women. The OR per pSAA activity unit was 0.95 [95% CI 0.92, 0.98] (p = 0.002) (pSAA activity range: 4.7 U/L to 65 U/L) in women. The association is driven largely by the highest levels of pSAA activity. The probability of having diabetes was significantly lower in the fifth pSAA activity quintile relative to the first (0.21 ± 0.03 (Q1) versus 0.82 ± 0.02 (Q5)), resulting in significantly reduced diabetes prevalence in Q5 in women. Our study indicates a beneficial effect of high pSAA activity, but not AMY1 CN, on diabetes odds in Qatari women, and suggests pSAA activity levels as a potential marker to predict future diabetes in Qatari women.Neyla S. Al-AklRichard Ian ThompsonAbdelilah ArredouaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Neyla S. Al-Akl Richard Ian Thompson Abdelilah Arredouani Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study |
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Abstract The association of salivary α-amylase activity (SAA) activity or low copy number of its coding gene AMY1 with diabetes remains controversial. We aimed to reinvestigate the association of these factors with diabetes in Qatar, where diabetes prevalence is about 16%. We obtained cross-sectional data of 929 Qataris (age > 18 years) from the Qatar Biobank. We estimated AMY1 copy number variants (CNV) from whole-genome data, and quantified the SAA activity in plasma (pSAA). We used adjusted logistic regression to examine the association between pSAA activity or AMY1 CNV and diabetes odds. We found a significant association between high pSAA activity, but not AMY1 CNV, and reduced odds of diabetes in Qatari women. The OR per pSAA activity unit was 0.95 [95% CI 0.92, 0.98] (p = 0.002) (pSAA activity range: 4.7 U/L to 65 U/L) in women. The association is driven largely by the highest levels of pSAA activity. The probability of having diabetes was significantly lower in the fifth pSAA activity quintile relative to the first (0.21 ± 0.03 (Q1) versus 0.82 ± 0.02 (Q5)), resulting in significantly reduced diabetes prevalence in Q5 in women. Our study indicates a beneficial effect of high pSAA activity, but not AMY1 CN, on diabetes odds in Qatari women, and suggests pSAA activity levels as a potential marker to predict future diabetes in Qatari women. |
format |
article |
author |
Neyla S. Al-Akl Richard Ian Thompson Abdelilah Arredouani |
author_facet |
Neyla S. Al-Akl Richard Ian Thompson Abdelilah Arredouani |
author_sort |
Neyla S. Al-Akl |
title |
Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study |
title_short |
Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study |
title_full |
Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study |
title_fullStr |
Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study |
title_full_unstemmed |
Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study |
title_sort |
reduced odds of diabetes associated with high plasma salivary α-amylase activity in qatari women: a cross-sectional study |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/828bca45b5a64158b72ba7d16f8d91a9 |
work_keys_str_mv |
AT neylasalakl reducedoddsofdiabetesassociatedwithhighplasmasalivaryaamylaseactivityinqatariwomenacrosssectionalstudy AT richardianthompson reducedoddsofdiabetesassociatedwithhighplasmasalivaryaamylaseactivityinqatariwomenacrosssectionalstudy AT abdelilaharredouani reducedoddsofdiabetesassociatedwithhighplasmasalivaryaamylaseactivityinqatariwomenacrosssectionalstudy |
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