ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma
In BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/829318fdf04b499a9e045b0d41cff81a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:829318fdf04b499a9e045b0d41cff81a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:829318fdf04b499a9e045b0d41cff81a2021-12-02T16:56:42ZERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma10.1038/s41467-017-02354-x2041-1723https://doaj.org/article/829318fdf04b499a9e045b0d41cff81a2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02354-xhttps://doaj.org/toc/2041-1723In BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors.Shujun HanYibo RenWangxiao HeHuadong LiuZhe ZhiXinliang ZhuTielin YangYu RongBohan MaTimothy J. PurwinZhenlin OuyangCaixia LiXun WangXueqiang WangHuizi YangYan ZhengAndrew E. AplinJiankang LiuYongping ShaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shujun Han Yibo Ren Wangxiao He Huadong Liu Zhe Zhi Xinliang Zhu Tielin Yang Yu Rong Bohan Ma Timothy J. Purwin Zhenlin Ouyang Caixia Li Xun Wang Xueqiang Wang Huizi Yang Yan Zheng Andrew E. Aplin Jiankang Liu Yongping Shao ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| description |
In BRAF mutant melanoma, inhibition of ERK1/2 induces FOXD3 and mediates RAF inhibitor resistance. Here, the authors show that ERK1/2 mediated phosphorylation regulates sumoylation of SOX10 which activates FOXD3, and depletion of SOX10 sensitises BRAF mutant melanoma cells to RAF inhibitors. |
| format |
article |
| author |
Shujun Han Yibo Ren Wangxiao He Huadong Liu Zhe Zhi Xinliang Zhu Tielin Yang Yu Rong Bohan Ma Timothy J. Purwin Zhenlin Ouyang Caixia Li Xun Wang Xueqiang Wang Huizi Yang Yan Zheng Andrew E. Aplin Jiankang Liu Yongping Shao |
| author_facet |
Shujun Han Yibo Ren Wangxiao He Huadong Liu Zhe Zhi Xinliang Zhu Tielin Yang Yu Rong Bohan Ma Timothy J. Purwin Zhenlin Ouyang Caixia Li Xun Wang Xueqiang Wang Huizi Yang Yan Zheng Andrew E. Aplin Jiankang Liu Yongping Shao |
| author_sort |
Shujun Han |
| title |
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_short |
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_full |
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_fullStr |
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_full_unstemmed |
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma |
| title_sort |
erk-mediated phosphorylation regulates sox10 sumoylation and targets expression in mutant braf melanoma |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/829318fdf04b499a9e045b0d41cff81a |
| work_keys_str_mv |
AT shujunhan erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT yiboren erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT wangxiaohe erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT huadongliu erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT zhezhi erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT xinliangzhu erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT tielinyang erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT yurong erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT bohanma erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT timothyjpurwin erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT zhenlinouyang erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT caixiali erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT xunwang erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT xueqiangwang erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT huiziyang erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT yanzheng erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT andreweaplin erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT jiankangliu erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma AT yongpingshao erkmediatedphosphorylationregulatessox10sumoylationandtargetsexpressioninmutantbrafmelanoma |
| _version_ |
1718382750194466816 |