NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, an...

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Autores principales:	Seungyong Lee, Charles Hwang, Simone Marini, Robert J. Tower, Qizhi Qin, Stefano Negri, Chase A. Pagani, Yuxiao Sun, David M. Stepien, Michael Sorkin, Carrie A. Kubiak, Noelle D. Visser, Carolyn A. Meyers, Yiyun Wang, Husain A. Rasheed, Jiajia Xu, Sarah Miller, Amanda K. Huber, Liliana Minichiello, Paul S. Cederna, Stephen W. P. Kemp, Thomas L. Clemens, Aaron W. James, Benjamin Levi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8294374ecf224a3ea40a708dc54a22e2
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spelling	oai:doaj.org-article:8294374ecf224a3ea40a708dc54a22e22021-12-02T15:10:55ZNGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma10.1038/s41467-021-25143-z2041-1723https://doaj.org/article/8294374ecf224a3ea40a708dc54a22e22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25143-zhttps://doaj.org/toc/2041-1723Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.Seungyong LeeCharles HwangSimone MariniRobert J. TowerQizhi QinStefano NegriChase A. PaganiYuxiao SunDavid M. StepienMichael SorkinCarrie A. KubiakNoelle D. VisserCarolyn A. MeyersYiyun WangHusain A. RasheedJiajia XuSarah MillerAmanda K. HuberLiliana MinichielloPaul S. CedernaStephen W. P. KempThomas L. ClemensAaron W. JamesBenjamin LeviNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seungyong Lee Charles Hwang Simone Marini Robert J. Tower Qizhi Qin Stefano Negri Chase A. Pagani Yuxiao Sun David M. Stepien Michael Sorkin Carrie A. Kubiak Noelle D. Visser Carolyn A. Meyers Yiyun Wang Husain A. Rasheed Jiajia Xu Sarah Miller Amanda K. Huber Liliana Minichiello Paul S. Cederna Stephen W. P. Kemp Thomas L. Clemens Aaron W. James Benjamin Levi NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
description	Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and drives abnormal osteochondral differentiation, and show that this process can be prevented by inhibition of NGF signaling.
format	article
author	Seungyong Lee Charles Hwang Simone Marini Robert J. Tower Qizhi Qin Stefano Negri Chase A. Pagani Yuxiao Sun David M. Stepien Michael Sorkin Carrie A. Kubiak Noelle D. Visser Carolyn A. Meyers Yiyun Wang Husain A. Rasheed Jiajia Xu Sarah Miller Amanda K. Huber Liliana Minichiello Paul S. Cederna Stephen W. P. Kemp Thomas L. Clemens Aaron W. James Benjamin Levi
author_facet	Seungyong Lee Charles Hwang Simone Marini Robert J. Tower Qizhi Qin Stefano Negri Chase A. Pagani Yuxiao Sun David M. Stepien Michael Sorkin Carrie A. Kubiak Noelle D. Visser Carolyn A. Meyers Yiyun Wang Husain A. Rasheed Jiajia Xu Sarah Miller Amanda K. Huber Liliana Minichiello Paul S. Cederna Stephen W. P. Kemp Thomas L. Clemens Aaron W. James Benjamin Levi
author_sort	Seungyong Lee
title	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
title_short	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
title_full	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
title_fullStr	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
title_full_unstemmed	NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
title_sort	ngf-trka signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8294374ecf224a3ea40a708dc54a22e2
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NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

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