The stem cell revolution: on the role of CD164 as a human stem cell marker

Abstract Accurately defining hierarchical relationships between human stem cells and their progeny, and using this knowledge for new cellular therapies, will undoubtedly lead to further successful treatments for life threatening and chronic diseases, which represent substantial burdens on patient qu...

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Autores principales:	Suzanne M. Watt, Hans-Jörg Bühring, Paul J. Simmons, Andrew W. C. Zannettino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/829dbc58af8249768c2ee9e676c43532
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spelling	oai:doaj.org-article:829dbc58af8249768c2ee9e676c435322021-12-02T17:34:47ZThe stem cell revolution: on the role of CD164 as a human stem cell marker10.1038/s41536-021-00143-12057-3995https://doaj.org/article/829dbc58af8249768c2ee9e676c435322021-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00143-1https://doaj.org/toc/2057-3995Abstract Accurately defining hierarchical relationships between human stem cells and their progeny, and using this knowledge for new cellular therapies, will undoubtedly lead to further successful treatments for life threatening and chronic diseases, which represent substantial burdens on patient quality of life and to healthcare systems globally. Clinical translation relies in part on appropriate biomarker, in vitro manipulation and transplantation strategies. CD164 has recently been cited as an important biomarker for enriching both human haematopoietic and skeletal stem cells, yet a thorough description of extant human CD164 monoclonal antibody (Mab) characteristics, which are critical for identifying and purifying these stem cells, was not discussed in these articles. Here, we highlight earlier but crucial research describing these relevant characteristics, including the differing human CD164 Mab avidities and their binding sites on the human CD164 sialomucin, which importantly may affect subsequent stem cell function and fate.Suzanne M. WattHans-Jörg BühringPaul J. SimmonsAndrew W. C. ZannettinoNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Suzanne M. Watt Hans-Jörg Bühring Paul J. Simmons Andrew W. C. Zannettino The stem cell revolution: on the role of CD164 as a human stem cell marker
description	Abstract Accurately defining hierarchical relationships between human stem cells and their progeny, and using this knowledge for new cellular therapies, will undoubtedly lead to further successful treatments for life threatening and chronic diseases, which represent substantial burdens on patient quality of life and to healthcare systems globally. Clinical translation relies in part on appropriate biomarker, in vitro manipulation and transplantation strategies. CD164 has recently been cited as an important biomarker for enriching both human haematopoietic and skeletal stem cells, yet a thorough description of extant human CD164 monoclonal antibody (Mab) characteristics, which are critical for identifying and purifying these stem cells, was not discussed in these articles. Here, we highlight earlier but crucial research describing these relevant characteristics, including the differing human CD164 Mab avidities and their binding sites on the human CD164 sialomucin, which importantly may affect subsequent stem cell function and fate.
format	article
author	Suzanne M. Watt Hans-Jörg Bühring Paul J. Simmons Andrew W. C. Zannettino
author_facet	Suzanne M. Watt Hans-Jörg Bühring Paul J. Simmons Andrew W. C. Zannettino
author_sort	Suzanne M. Watt
title	The stem cell revolution: on the role of CD164 as a human stem cell marker
title_short	The stem cell revolution: on the role of CD164 as a human stem cell marker
title_full	The stem cell revolution: on the role of CD164 as a human stem cell marker
title_fullStr	The stem cell revolution: on the role of CD164 as a human stem cell marker
title_full_unstemmed	The stem cell revolution: on the role of CD164 as a human stem cell marker
title_sort	stem cell revolution: on the role of cd164 as a human stem cell marker
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/829dbc58af8249768c2ee9e676c43532
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The stem cell revolution: on the role of CD164 as a human stem cell marker

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