Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization

Alkene isomerizations and asymmetric C–H functionalizations have been independently studied, but their combination in one protocol is uncommon. Here the authors show a palladium-catalyzed method to iteratively “walk” a terminal alkene along a carbon chain to a position next to styrenes where a soft...

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Autores principales:	Ye-Wei Chen, Yang Liu, Han-Yu Lu, Guo-Qiang Lin, Zhi-Tao He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82a069116af54d87b0e3803940d352e1
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spelling	oai:doaj.org-article:82a069116af54d87b0e3803940d352e12021-12-02T18:48:11ZPalladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization10.1038/s41467-021-25978-62041-1723https://doaj.org/article/82a069116af54d87b0e3803940d352e12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25978-6https://doaj.org/toc/2041-1723Alkene isomerizations and asymmetric C–H functionalizations have been independently studied, but their combination in one protocol is uncommon. Here the authors show a palladium-catalyzed method to iteratively “walk” a terminal alkene along a carbon chain to a position next to styrenes where a soft nucleophile is added asymmetrically.Ye-Wei ChenYang LiuHan-Yu LuGuo-Qiang LinZhi-Tao HeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ye-Wei Chen Yang Liu Han-Yu Lu Guo-Qiang Lin Zhi-Tao He Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization
description	Alkene isomerizations and asymmetric C–H functionalizations have been independently studied, but their combination in one protocol is uncommon. Here the authors show a palladium-catalyzed method to iteratively “walk” a terminal alkene along a carbon chain to a position next to styrenes where a soft nucleophile is added asymmetrically.
format	article
author	Ye-Wei Chen Yang Liu Han-Yu Lu Guo-Qiang Lin Zhi-Tao He
author_facet	Ye-Wei Chen Yang Liu Han-Yu Lu Guo-Qiang Lin Zhi-Tao He
author_sort	Ye-Wei Chen
title	Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization
title_short	Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization
title_full	Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization
title_fullStr	Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization
title_full_unstemmed	Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization
title_sort	palladium-catalyzed regio- and enantioselective migratory allylic c(sp3)-h functionalization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82a069116af54d87b0e3803940d352e1
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Palladium-catalyzed regio- and enantioselective migratory allylic C(sp3)-H functionalization

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