Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients

Hany Mahmoud,1 Ahmed Hamody,2 Hesham M Hefny,3 Dalia Tohamy,4 Islam Awny5 1Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt; 2Anesthesia Department, Sohag University, Sohag, Egypt; 3Clinical Pathology Department, Sohag University, Sohag, Egypt; 4Ophthalmology Departme...

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Autores principales:	Mahmoud H, Hamody A, M Hefny H, Tohamy D, Awny I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	anti-sars-cov-2 iga ocular secretions swab. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/82a0cf5c901c4f118e81885a996f6222
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spelling	oai:doaj.org-article:82a0cf5c901c4f118e81885a996f62222021-12-02T16:58:09ZEvaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients1177-5483https://doaj.org/article/82a0cf5c901c4f118e81885a996f62222021-05-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-anti-sars-cov-2-iga-in-the-conjunctival-secretions-of-co-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Hany Mahmoud,1 Ahmed Hamody,2 Hesham M Hefny,3 Dalia Tohamy,4 Islam Awny5 1Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt; 2Anesthesia Department, Sohag University, Sohag, Egypt; 3Clinical Pathology Department, Sohag University, Sohag, Egypt; 4Ophthalmology Department, Assiut University, Assiut, Egypt; 5Department of Ophthalmology, Sohag University, Sohag, EgyptCorrespondence: Hany MahmoudDepartment of Ophthalmology, Faculty of Medicine, Sohag University, EgyptTel +20 1024368111Email drhanymahmoud@gmail.comPurpose: To assess the presence of anti-SARS-CoV-2 IgA in the conjunctival secretions of confirmed COVID-19 patients by nasopharyngeal swabs and correlate its presence with the severity of the disease, patient’s age, sex and ocular symptoms.Methods: This study included 44 positive COVID-19 patients confirmed with nasopharyngeal swabs during the period 17– 28 February 2021 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions were examined for the presence of anti-SARS-CoV-2 IgA.Results: While non-reactive results are strongly correlated to low titre and vice versa, severity showed significant correlation with neither IgA reactivity nor titre. Meanwhile, IgA reactivity did not show significant correlation with either age or sex. The reactivity and IgA titre are correlated with ocular symptoms.Conclusion: The anti-SARS-CoV-2 IgA could be found in ocular secretions in SARS-CoV-2 patients. There is no correlation with age or sex or severity of the disease; however, they are correlated with ocular symptoms.Keywords: anti-SARS-CoV-2 IgA, ocular, secretions, swabMahmoud HHamody AM Hefny HTohamy DAwny IDove Medical Pressarticleanti-sars-cov-2 igaocularsecretionsswab.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1933-1937 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-sars-cov-2 iga ocular secretions swab. Ophthalmology RE1-994
spellingShingle	anti-sars-cov-2 iga ocular secretions swab. Ophthalmology RE1-994 Mahmoud H Hamody A M Hefny H Tohamy D Awny I Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients
description	Hany Mahmoud,1 Ahmed Hamody,2 Hesham M Hefny,3 Dalia Tohamy,4 Islam Awny5 1Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt; 2Anesthesia Department, Sohag University, Sohag, Egypt; 3Clinical Pathology Department, Sohag University, Sohag, Egypt; 4Ophthalmology Department, Assiut University, Assiut, Egypt; 5Department of Ophthalmology, Sohag University, Sohag, EgyptCorrespondence: Hany MahmoudDepartment of Ophthalmology, Faculty of Medicine, Sohag University, EgyptTel +20 1024368111Email drhanymahmoud@gmail.comPurpose: To assess the presence of anti-SARS-CoV-2 IgA in the conjunctival secretions of confirmed COVID-19 patients by nasopharyngeal swabs and correlate its presence with the severity of the disease, patient’s age, sex and ocular symptoms.Methods: This study included 44 positive COVID-19 patients confirmed with nasopharyngeal swabs during the period 17– 28 February 2021 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions were examined for the presence of anti-SARS-CoV-2 IgA.Results: While non-reactive results are strongly correlated to low titre and vice versa, severity showed significant correlation with neither IgA reactivity nor titre. Meanwhile, IgA reactivity did not show significant correlation with either age or sex. The reactivity and IgA titre are correlated with ocular symptoms.Conclusion: The anti-SARS-CoV-2 IgA could be found in ocular secretions in SARS-CoV-2 patients. There is no correlation with age or sex or severity of the disease; however, they are correlated with ocular symptoms.Keywords: anti-SARS-CoV-2 IgA, ocular, secretions, swab
format	article
author	Mahmoud H Hamody A M Hefny H Tohamy D Awny I
author_facet	Mahmoud H Hamody A M Hefny H Tohamy D Awny I
author_sort	Mahmoud H
title	Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients
title_short	Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients
title_full	Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients
title_fullStr	Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients
title_full_unstemmed	Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients
title_sort	evaluation of anti-sars-cov-2 iga in the conjunctival secretions of covid-19 patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/82a0cf5c901c4f118e81885a996f6222
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Evaluation of Anti-SARS-CoV-2 IgA in the Conjunctival Secretions of COVID-19 Patients

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