Combination of arsenic and interferon-α inhibits expression of KSHV latent transcripts and synergistically improves survival of mice with primary effusion lymphomas.

Combination of arsenic and interferon-α inhibits expression of KSHV latent transcripts and synergistically improves survival of mice with primary effusion lymphomas.

<h4>Background</h4>Kaposi sarcoma-associated herpesvirus (KSHV) is the etiologic agent of primary effusion lymphomas (PEL). PEL cell lines infected with KSHV, but negative for Epstein-Barr virus have a tumorigenic potential in non-obese diabetic/severe combined immunodeficient mice and r...

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Autores principales: Hiba El Hajj, Jihane Ali, Akram Ghantous, Dana Hodroj, Ahmad Daher, Kazem Zibara, Chloé Journo, Zaher Otrock, Ghazi Zaatari, Renaud Mahieux, Marwan El Sabban, Ali Bazarbachi, Raghida Abou Merhi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/82a3ce35772b42f6be4136d67223f89e
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