Sex differences and autism: brain function during verbal fluency and mental rotation.

Autism spectrum conditions (ASC) affect more males than females. This suggests that the neurobiology of autism: 1) may overlap with mechanisms underlying typical sex-differentiation or 2) alternately reflect sex-specificity in how autism is expressed in males and females. Here we used functional mag...

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Autores principales:	Felix D C C Beacher, Eugenia Radulescu, Ludovico Minati, Simon Baron-Cohen, Michael V Lombardo, Meng-Chuan Lai, Anne Walker, Dawn Howard, Marcus A Gray, Neil A Harrison, Hugo D Critchley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/82a4954a1aca4ef98031a3fcfe35485d
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spelling	oai:doaj.org-article:82a4954a1aca4ef98031a3fcfe35485d2021-11-18T07:15:46ZSex differences and autism: brain function during verbal fluency and mental rotation.1932-620310.1371/journal.pone.0038355https://doaj.org/article/82a4954a1aca4ef98031a3fcfe35485d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22701630/?tool=EBIhttps://doaj.org/toc/1932-6203Autism spectrum conditions (ASC) affect more males than females. This suggests that the neurobiology of autism: 1) may overlap with mechanisms underlying typical sex-differentiation or 2) alternately reflect sex-specificity in how autism is expressed in males and females. Here we used functional magnetic resonance imaging (fMRI) to test these alternate hypotheses. Fifteen men and fourteen women with Asperger syndrome (AS), and sixteen typically developing men and sixteen typically developing women underwent fMRI during performance of mental rotation and verbal fluency tasks. All groups performed the tasks equally well. On the verbal fluency task, despite equivalent task-performance, both males and females with AS showed enhanced activation of left occipitoparietal and inferior prefrontal activity compared to controls. During mental rotation, there was a significant diagnosis-by-sex interaction across occipital, temporal, parietal, middle frontal regions, with greater activation in AS males and typical females compared to AS females and typical males. These findings suggest a complex relationship between autism and sex that is differentially expressed in verbal and visuospatial domains.Felix D C C BeacherEugenia RadulescuLudovico MinatiSimon Baron-CohenMichael V LombardoMeng-Chuan LaiAnne WalkerDawn HowardMarcus A GrayNeil A HarrisonHugo D CritchleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38355 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Felix D C C Beacher Eugenia Radulescu Ludovico Minati Simon Baron-Cohen Michael V Lombardo Meng-Chuan Lai Anne Walker Dawn Howard Marcus A Gray Neil A Harrison Hugo D Critchley Sex differences and autism: brain function during verbal fluency and mental rotation.
description	Autism spectrum conditions (ASC) affect more males than females. This suggests that the neurobiology of autism: 1) may overlap with mechanisms underlying typical sex-differentiation or 2) alternately reflect sex-specificity in how autism is expressed in males and females. Here we used functional magnetic resonance imaging (fMRI) to test these alternate hypotheses. Fifteen men and fourteen women with Asperger syndrome (AS), and sixteen typically developing men and sixteen typically developing women underwent fMRI during performance of mental rotation and verbal fluency tasks. All groups performed the tasks equally well. On the verbal fluency task, despite equivalent task-performance, both males and females with AS showed enhanced activation of left occipitoparietal and inferior prefrontal activity compared to controls. During mental rotation, there was a significant diagnosis-by-sex interaction across occipital, temporal, parietal, middle frontal regions, with greater activation in AS males and typical females compared to AS females and typical males. These findings suggest a complex relationship between autism and sex that is differentially expressed in verbal and visuospatial domains.
format	article
author	Felix D C C Beacher Eugenia Radulescu Ludovico Minati Simon Baron-Cohen Michael V Lombardo Meng-Chuan Lai Anne Walker Dawn Howard Marcus A Gray Neil A Harrison Hugo D Critchley
author_facet	Felix D C C Beacher Eugenia Radulescu Ludovico Minati Simon Baron-Cohen Michael V Lombardo Meng-Chuan Lai Anne Walker Dawn Howard Marcus A Gray Neil A Harrison Hugo D Critchley
author_sort	Felix D C C Beacher
title	Sex differences and autism: brain function during verbal fluency and mental rotation.
title_short	Sex differences and autism: brain function during verbal fluency and mental rotation.
title_full	Sex differences and autism: brain function during verbal fluency and mental rotation.
title_fullStr	Sex differences and autism: brain function during verbal fluency and mental rotation.
title_full_unstemmed	Sex differences and autism: brain function during verbal fluency and mental rotation.
title_sort	sex differences and autism: brain function during verbal fluency and mental rotation.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/82a4954a1aca4ef98031a3fcfe35485d
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Sex differences and autism: brain function during verbal fluency and mental rotation.

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