Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.

Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood. Therefore, the present study was aimed at investigating whether variation in schizophrenia-relat...

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Autores principales:	Sebastian Ocklenburg, Larissa Arning, Wanda M Gerding, Jörg T Epplen, Onur Güntürkün, Christian Beste
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/82a8342dfd6d4dfcbe0125195ef34623
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spelling	oai:doaj.org-article:82a8342dfd6d4dfcbe0125195ef346232021-11-18T08:01:39ZCholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.1932-620310.1371/journal.pone.0053643https://doaj.org/article/82a8342dfd6d4dfcbe0125195ef346232013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23341962/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood. Therefore, the present study was aimed at investigating whether variation in schizophrenia-related genes modulates individual lateralization patterns. To this end, we genotyped 16 single nucleotide polymorphisms that have previously been linked to schizophrenia on a meta-analysis level in a sample of 444 genetically unrelated healthy participants and examined the association of these polymorphisms with handedness, footedness and language lateralization. We found a significant association of the cholecystokinin-A receptor (CCKAR) gene variation rs1800857 and language lateralization assessed using the dichotic listening task. Individuals carrying the schizophrenia risk allele C of this polymorphism showed a marked reduction of the typical left-hemispheric dominance for language processing. Since the cholecystokinin A receptor is involved in dopamine release in the central nervous system, these findings suggest that genetic variation in this receptor may modulate language lateralization due to its impact on dopaminergic pathways.Sebastian OcklenburgLarissa ArningWanda M GerdingJörg T EpplenOnur GüntürkünChristian BestePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53643 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sebastian Ocklenburg Larissa Arning Wanda M Gerding Jörg T Epplen Onur Güntürkün Christian Beste Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
description	Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood. Therefore, the present study was aimed at investigating whether variation in schizophrenia-related genes modulates individual lateralization patterns. To this end, we genotyped 16 single nucleotide polymorphisms that have previously been linked to schizophrenia on a meta-analysis level in a sample of 444 genetically unrelated healthy participants and examined the association of these polymorphisms with handedness, footedness and language lateralization. We found a significant association of the cholecystokinin-A receptor (CCKAR) gene variation rs1800857 and language lateralization assessed using the dichotic listening task. Individuals carrying the schizophrenia risk allele C of this polymorphism showed a marked reduction of the typical left-hemispheric dominance for language processing. Since the cholecystokinin A receptor is involved in dopamine release in the central nervous system, these findings suggest that genetic variation in this receptor may modulate language lateralization due to its impact on dopaminergic pathways.
format	article
author	Sebastian Ocklenburg Larissa Arning Wanda M Gerding Jörg T Epplen Onur Güntürkün Christian Beste
author_facet	Sebastian Ocklenburg Larissa Arning Wanda M Gerding Jörg T Epplen Onur Güntürkün Christian Beste
author_sort	Sebastian Ocklenburg
title	Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
title_short	Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
title_full	Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
title_fullStr	Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
title_full_unstemmed	Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
title_sort	cholecystokinin a receptor (cckar) gene variation is associated with language lateralization.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/82a8342dfd6d4dfcbe0125195ef34623
work_keys_str_mv	AT sebastianocklenburg cholecystokininareceptorcckargenevariationisassociatedwithlanguagelateralization AT larissaarning cholecystokininareceptorcckargenevariationisassociatedwithlanguagelateralization AT wandamgerding cholecystokininareceptorcckargenevariationisassociatedwithlanguagelateralization AT jorgtepplen cholecystokininareceptorcckargenevariationisassociatedwithlanguagelateralization AT onurgunturkun cholecystokininareceptorcckargenevariationisassociatedwithlanguagelateralization AT christianbeste cholecystokininareceptorcckargenevariationisassociatedwithlanguagelateralization
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Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.

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