Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation

Emerging experimental observation suggests that asymmetrical partitioning in cell division plays an important role in cell-to-cell variability, cell fate determination, cellular aging, and rejuvenation. Here, the authors propose a method based on multicolor flow cytometry to measure asymmetric divis...

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Autores principales:	Giovanna Peruzzi, Mattia Miotto, Roberta Maggio, Giancarlo Ruocco, Giorgio Gosti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Astrophysics QB460-466 Physics QC1-999
Acceso en línea:	https://doaj.org/article/82ad4783d6dc443695fab71a6b0b9a4a
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spelling	oai:doaj.org-article:82ad4783d6dc443695fab71a6b0b9a4a2021-12-02T17:08:24ZAsymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation10.1038/s42005-021-00690-52399-3650https://doaj.org/article/82ad4783d6dc443695fab71a6b0b9a4a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42005-021-00690-5https://doaj.org/toc/2399-3650Emerging experimental observation suggests that asymmetrical partitioning in cell division plays an important role in cell-to-cell variability, cell fate determination, cellular aging, and rejuvenation. Here, the authors propose a method based on multicolor flow cytometry to measure asymmetric division of cellular organelles, finding that cell cytoplasm is divided symmetrically but mitochondria and membrane lipids are asymmetrically distributed, and explain these observations through a minimal model of asymmetric partitioning based on biased binomial statistics.Giovanna PeruzziMattia MiottoRoberta MaggioGiancarlo RuoccoGiorgio GostiNature PortfolioarticleAstrophysicsQB460-466PhysicsQC1-999ENCommunications Physics, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Astrophysics QB460-466 Physics QC1-999
spellingShingle	Astrophysics QB460-466 Physics QC1-999 Giovanna Peruzzi Mattia Miotto Roberta Maggio Giancarlo Ruocco Giorgio Gosti Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation
description	Emerging experimental observation suggests that asymmetrical partitioning in cell division plays an important role in cell-to-cell variability, cell fate determination, cellular aging, and rejuvenation. Here, the authors propose a method based on multicolor flow cytometry to measure asymmetric division of cellular organelles, finding that cell cytoplasm is divided symmetrically but mitochondria and membrane lipids are asymmetrically distributed, and explain these observations through a minimal model of asymmetric partitioning based on biased binomial statistics.
format	article
author	Giovanna Peruzzi Mattia Miotto Roberta Maggio Giancarlo Ruocco Giorgio Gosti
author_facet	Giovanna Peruzzi Mattia Miotto Roberta Maggio Giancarlo Ruocco Giorgio Gosti
author_sort	Giovanna Peruzzi
title	Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation
title_short	Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation
title_full	Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation
title_fullStr	Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation
title_full_unstemmed	Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation
title_sort	asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82ad4783d6dc443695fab71a6b0b9a4a
work_keys_str_mv	AT giovannaperuzzi asymmetricbinomialstatisticsexplainsorganellepartitioningvarianceincancercellproliferation AT mattiamiotto asymmetricbinomialstatisticsexplainsorganellepartitioningvarianceincancercellproliferation AT robertamaggio asymmetricbinomialstatisticsexplainsorganellepartitioningvarianceincancercellproliferation AT giancarloruocco asymmetricbinomialstatisticsexplainsorganellepartitioningvarianceincancercellproliferation AT giorgiogosti asymmetricbinomialstatisticsexplainsorganellepartitioningvarianceincancercellproliferation
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Asymmetric binomial statistics explains organelle partitioning variance in cancer cell proliferation

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