CSL controls telomere maintenance and genome stability in human dermal fibroblasts

CSL controls telomere maintenance and genome stability in human dermal fibroblasts

Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal fibroblasts and CAFs.

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Auteurs principaux: Giulia Bottoni, Atul Katarkar, Beatrice Tassone, Soumitra Ghosh, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Paris Jafari, Fabio Tordini, Thomas Lunardi, Wolfram Hoetzenecker, Victor Neel, Joachim Lingner, G. Paolo Dotto
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Science
Q
Accès en ligne:https://doaj.org/article/82b5056962d14041aae036cba6d017e3
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spelling oai:doaj.org-article:82b5056962d14041aae036cba6d017e32021-12-02T16:58:25ZCSL controls telomere maintenance and genome stability in human dermal fibroblasts10.1038/s41467-019-11785-72041-1723https://doaj.org/article/82b5056962d14041aae036cba6d017e32019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11785-7https://doaj.org/toc/2041-1723Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal fibroblasts and CAFs.Giulia BottoniAtul KatarkarBeatrice TassoneSoumitra GhoshAndrea ClocchiattiSandro GoruppiPino BordignonParis JafariFabio TordiniThomas LunardiWolfram HoetzeneckerVictor NeelJoachim LingnerG. Paolo DottoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Giulia Bottoni
Atul Katarkar
Beatrice Tassone
Soumitra Ghosh
Andrea Clocchiatti
Sandro Goruppi
Pino Bordignon
Paris Jafari
Fabio Tordini
Thomas Lunardi
Wolfram Hoetzenecker
Victor Neel
Joachim Lingner
G. Paolo Dotto
CSL controls telomere maintenance and genome stability in human dermal fibroblasts
description Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal fibroblasts and CAFs.
format article
author Giulia Bottoni
Atul Katarkar
Beatrice Tassone
Soumitra Ghosh
Andrea Clocchiatti
Sandro Goruppi
Pino Bordignon
Paris Jafari
Fabio Tordini
Thomas Lunardi
Wolfram Hoetzenecker
Victor Neel
Joachim Lingner
G. Paolo Dotto
author_facet Giulia Bottoni
Atul Katarkar
Beatrice Tassone
Soumitra Ghosh
Andrea Clocchiatti
Sandro Goruppi
Pino Bordignon
Paris Jafari
Fabio Tordini
Thomas Lunardi
Wolfram Hoetzenecker
Victor Neel
Joachim Lingner
G. Paolo Dotto
author_sort Giulia Bottoni
title CSL controls telomere maintenance and genome stability in human dermal fibroblasts
title_short CSL controls telomere maintenance and genome stability in human dermal fibroblasts
title_full CSL controls telomere maintenance and genome stability in human dermal fibroblasts
title_fullStr CSL controls telomere maintenance and genome stability in human dermal fibroblasts
title_full_unstemmed CSL controls telomere maintenance and genome stability in human dermal fibroblasts
title_sort csl controls telomere maintenance and genome stability in human dermal fibroblasts
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/82b5056962d14041aae036cba6d017e3
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