Blowing Hot and Cold: Body Temperature and the Microbiome

ABSTRACT The intestinal microbiome influences host health, and its responsiveness to diet and disease is increasingly well studied. However, our understanding of the factors driving microbiome variation remain limited. Temperature is a core factor that controls microbial growth, but its impact on th...

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Autores principales:	Kelsey E. Huus, Ruth E. Ley
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	fever human microbiome microbiome temperature heat stress, hypothermia Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/82bc2ba969d643ee872dc9bec9c91f2d
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id	oai:doaj.org-article:82bc2ba969d643ee872dc9bec9c91f2d
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spelling	oai:doaj.org-article:82bc2ba969d643ee872dc9bec9c91f2d2021-12-02T17:51:37ZBlowing Hot and Cold: Body Temperature and the Microbiome10.1128/mSystems.00707-212379-5077https://doaj.org/article/82bc2ba969d643ee872dc9bec9c91f2d2021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00707-21https://doaj.org/toc/2379-5077ABSTRACT The intestinal microbiome influences host health, and its responsiveness to diet and disease is increasingly well studied. However, our understanding of the factors driving microbiome variation remain limited. Temperature is a core factor that controls microbial growth, but its impact on the microbiome remains to be fully explored. Although commonly assumed to be a constant 37°C, normal body temperatures vary across the animal kingdom, while individual body temperature is affected by multiple factors, including circadian rhythm, age, environmental temperature stress, and immune activation. Changes in body temperature via hypo- and hyperthermia have been shown to influence the gut microbiota in a variety of animals, with consistent effects on community diversity and stability. It is known that temperature directly modulates the growth and virulence of gastrointestinal pathogens; however, the effect of temperature on gut commensals is not well studied. Further, body temperature can influence other host factors, such as appetite and immunity, with indirect effects on the microbiome. In this minireview, we discuss the evidence linking body temperature and the intestinal microbiome and their implications for microbiome function during hypothermia, heat stress, and fever.Kelsey E. HuusRuth E. LeyAmerican Society for Microbiologyarticlefeverhuman microbiomemicrobiometemperatureheat stress, hypothermiaMicrobiologyQR1-502ENmSystems, Vol 6, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fever human microbiome microbiome temperature heat stress, hypothermia Microbiology QR1-502
spellingShingle	fever human microbiome microbiome temperature heat stress, hypothermia Microbiology QR1-502 Kelsey E. Huus Ruth E. Ley Blowing Hot and Cold: Body Temperature and the Microbiome
description	ABSTRACT The intestinal microbiome influences host health, and its responsiveness to diet and disease is increasingly well studied. However, our understanding of the factors driving microbiome variation remain limited. Temperature is a core factor that controls microbial growth, but its impact on the microbiome remains to be fully explored. Although commonly assumed to be a constant 37°C, normal body temperatures vary across the animal kingdom, while individual body temperature is affected by multiple factors, including circadian rhythm, age, environmental temperature stress, and immune activation. Changes in body temperature via hypo- and hyperthermia have been shown to influence the gut microbiota in a variety of animals, with consistent effects on community diversity and stability. It is known that temperature directly modulates the growth and virulence of gastrointestinal pathogens; however, the effect of temperature on gut commensals is not well studied. Further, body temperature can influence other host factors, such as appetite and immunity, with indirect effects on the microbiome. In this minireview, we discuss the evidence linking body temperature and the intestinal microbiome and their implications for microbiome function during hypothermia, heat stress, and fever.
format	article
author	Kelsey E. Huus Ruth E. Ley
author_facet	Kelsey E. Huus Ruth E. Ley
author_sort	Kelsey E. Huus
title	Blowing Hot and Cold: Body Temperature and the Microbiome
title_short	Blowing Hot and Cold: Body Temperature and the Microbiome
title_full	Blowing Hot and Cold: Body Temperature and the Microbiome
title_fullStr	Blowing Hot and Cold: Body Temperature and the Microbiome
title_full_unstemmed	Blowing Hot and Cold: Body Temperature and the Microbiome
title_sort	blowing hot and cold: body temperature and the microbiome
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/82bc2ba969d643ee872dc9bec9c91f2d
work_keys_str_mv	AT kelseyehuus blowinghotandcoldbodytemperatureandthemicrobiome AT rutheley blowinghotandcoldbodytemperatureandthemicrobiome
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Blowing Hot and Cold: Body Temperature and the Microbiome

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