Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure

Xi Wang, Fan Wang, Minzhi Chen, Xiaona Wang, Jin Zheng, Aimei Qin Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China Purpose: Increased variability in blood pressure (BP) is known to be closely associated with the development, progression and severity of renal damage...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang X, Wang F, Chen M, Zheng J, Qin A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Hypertension Elderly male Blood pressure variability Estimated glomerular filtration rate Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/82c1eb003d7348d8aeced6bb1360fa1f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:82c1eb003d7348d8aeced6bb1360fa1f
record_format	dspace
spelling	oai:doaj.org-article:82c1eb003d7348d8aeced6bb1360fa1f2021-12-02T07:37:57ZTwenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure1178-1998https://doaj.org/article/82c1eb003d7348d8aeced6bb1360fa1f2018-04-01T00:00:00Zhttps://www.dovepress.com/twenty-four-hour-systolic-blood-pressure-variability-and-renal-functio-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xi Wang, Fan Wang, Minzhi Chen, Xiaona Wang, Jin Zheng, Aimei Qin Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China Purpose: Increased variability in blood pressure (BP) is known to be closely associated with the development, progression and severity of renal damage in patients with chronic kidney disease. However, little is known about the association of BP variability (BPV) with the decline of renal function in elderly hypertensive patients with well-controlled BP. We, therefore, aimed to investigate the association between BPV and glomerular filtration rate in hypertensive elderly (age >60 years) and very elderly (age >80 years) male patients with BP controlled within the normal range by antihypertensive therapy.Patients and methods: This study involved 484 hospitalized elderly male hypertensive patients with BP controlled within the normal range by antihypertensive therapy. BPV was defined as the SD from mean BP over a 24 h period. Renal function was estimated by estimated glomerular filtration rate (eGFR) which was calculated by the Chinese modified Modification of Diet in Renal Disease Equation. Participants were divided into three groups according to their eGFR data. Multivariate linear regression was then used to analyze the correlation between eGFR and BPV.Results: The 24 h systolic BP (SBP) variability increased as eGFR decreased. There was no significant difference in 24 h SBP variability when compared between elderly and very elderly hypertensive patients. Multivariate linear regression analysis showed that SBP variability demonstrated a negative linear relationship with eGFR (P<0.05) after adjustment for potential confounding factors.Conclusion: Among the parameters of 24 h ambulatory BP monitoring, 24 h SBP variability is the only independent risk factor for a decline in renal function in elderly and very elderly male hypertensive patients with well-controlled BP. Keywords: hypertension, elderly male, blood pressure variability, estimated glomerular filtration rateWang XWang FChen MWang XZheng JQin ADove Medical PressarticleHypertensionElderly maleBlood pressure variabilityEstimated glomerular filtration rateGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 533-540 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypertension Elderly male Blood pressure variability Estimated glomerular filtration rate Geriatrics RC952-954.6
spellingShingle	Hypertension Elderly male Blood pressure variability Estimated glomerular filtration rate Geriatrics RC952-954.6 Wang X Wang F Chen M Wang X Zheng J Qin A Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure
description	Xi Wang, Fan Wang, Minzhi Chen, Xiaona Wang, Jin Zheng, Aimei Qin Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China Purpose: Increased variability in blood pressure (BP) is known to be closely associated with the development, progression and severity of renal damage in patients with chronic kidney disease. However, little is known about the association of BP variability (BPV) with the decline of renal function in elderly hypertensive patients with well-controlled BP. We, therefore, aimed to investigate the association between BPV and glomerular filtration rate in hypertensive elderly (age >60 years) and very elderly (age >80 years) male patients with BP controlled within the normal range by antihypertensive therapy.Patients and methods: This study involved 484 hospitalized elderly male hypertensive patients with BP controlled within the normal range by antihypertensive therapy. BPV was defined as the SD from mean BP over a 24 h period. Renal function was estimated by estimated glomerular filtration rate (eGFR) which was calculated by the Chinese modified Modification of Diet in Renal Disease Equation. Participants were divided into three groups according to their eGFR data. Multivariate linear regression was then used to analyze the correlation between eGFR and BPV.Results: The 24 h systolic BP (SBP) variability increased as eGFR decreased. There was no significant difference in 24 h SBP variability when compared between elderly and very elderly hypertensive patients. Multivariate linear regression analysis showed that SBP variability demonstrated a negative linear relationship with eGFR (P<0.05) after adjustment for potential confounding factors.Conclusion: Among the parameters of 24 h ambulatory BP monitoring, 24 h SBP variability is the only independent risk factor for a decline in renal function in elderly and very elderly male hypertensive patients with well-controlled BP. Keywords: hypertension, elderly male, blood pressure variability, estimated glomerular filtration rate
format	article
author	Wang X Wang F Chen M Wang X Zheng J Qin A
author_facet	Wang X Wang F Chen M Wang X Zheng J Qin A
author_sort	Wang X
title	Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure
title_short	Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure
title_full	Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure
title_fullStr	Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure
title_full_unstemmed	Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure
title_sort	twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/82c1eb003d7348d8aeced6bb1360fa1f
work_keys_str_mv	AT wangx twentyfourhoursystolicbloodpressurevariabilityandrenalfunctiondeclineinelderlymalehypertensivepatientswithwellcontrolledbloodpressure AT wangf twentyfourhoursystolicbloodpressurevariabilityandrenalfunctiondeclineinelderlymalehypertensivepatientswithwellcontrolledbloodpressure AT chenm twentyfourhoursystolicbloodpressurevariabilityandrenalfunctiondeclineinelderlymalehypertensivepatientswithwellcontrolledbloodpressure AT wangx twentyfourhoursystolicbloodpressurevariabilityandrenalfunctiondeclineinelderlymalehypertensivepatientswithwellcontrolledbloodpressure AT zhengj twentyfourhoursystolicbloodpressurevariabilityandrenalfunctiondeclineinelderlymalehypertensivepatientswithwellcontrolledbloodpressure AT qina twentyfourhoursystolicbloodpressurevariabilityandrenalfunctiondeclineinelderlymalehypertensivepatientswithwellcontrolledbloodpressure
_version_	1718399292783198208

Twenty-four-hour systolic blood pressure variability and renal function decline in elderly male hypertensive patients with well-controlled blood pressure

Ejemplares similares