The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

DEAD-box helicases (DDXs) function in an ATP-dependent, non-processive manner and the conserved helicase core is composed of two RecA-like domains D1 and D2. Here the authors present the crystal structure of the D1D2 core from human DDX3X bound to a 23-base pair dsRNA in the pre-unwound state and di...

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Autores principales:	He Song, Xinhua Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82c3708a869a4a2e8d850a61575d5c30
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spelling	oai:doaj.org-article:82c3708a869a4a2e8d850a61575d5c302021-12-02T14:39:19ZThe mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X10.1038/s41467-019-11083-22041-1723https://doaj.org/article/82c3708a869a4a2e8d850a61575d5c302019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11083-2https://doaj.org/toc/2041-1723DEAD-box helicases (DDXs) function in an ATP-dependent, non-processive manner and the conserved helicase core is composed of two RecA-like domains D1 and D2. Here the authors present the crystal structure of the D1D2 core from human DDX3X bound to a 23-base pair dsRNA in the pre-unwound state and discuss the implications for helicase mechanism.He SongXinhua JiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q He Song Xinhua Ji The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
description	DEAD-box helicases (DDXs) function in an ATP-dependent, non-processive manner and the conserved helicase core is composed of two RecA-like domains D1 and D2. Here the authors present the crystal structure of the D1D2 core from human DDX3X bound to a 23-base pair dsRNA in the pre-unwound state and discuss the implications for helicase mechanism.
format	article
author	He Song Xinhua Ji
author_facet	He Song Xinhua Ji
author_sort	He Song
title	The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
title_short	The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
title_full	The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
title_fullStr	The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
title_full_unstemmed	The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
title_sort	mechanism of rna duplex recognition and unwinding by dead-box helicase ddx3x
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/82c3708a869a4a2e8d850a61575d5c30
work_keys_str_mv	AT hesong themechanismofrnaduplexrecognitionandunwindingbydeadboxhelicaseddx3x AT xinhuaji themechanismofrnaduplexrecognitionandunwindingbydeadboxhelicaseddx3x AT hesong mechanismofrnaduplexrecognitionandunwindingbydeadboxhelicaseddx3x AT xinhuaji mechanismofrnaduplexrecognitionandunwindingbydeadboxhelicaseddx3x
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The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

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