MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN

Objective: Immun-component children with moderate neutropenia do not have an increased risk for severe bacterial infections. However, there is limited data for the management of benign neutropenia in children. Therefore, we aimed to determine the most common etiology and outcomes in children with ne...

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Autores principales:	Hatice Mine Cakmak, Omer Kartal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/82cd836e70064c228f9cb1f65dbe4417
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spelling	oai:doaj.org-article:82cd836e70064c228f9cb1f65dbe44172021-11-10T04:33:23ZMANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN2531-137910.1016/j.htct.2021.10.990https://doaj.org/article/82cd836e70064c228f9cb1f65dbe44172021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011378https://doaj.org/toc/2531-1379Objective: Immun-component children with moderate neutropenia do not have an increased risk for severe bacterial infections. However, there is limited data for the management of benign neutropenia in children. Therefore, we aimed to determine the most common etiology and outcomes in children with neutropenia. In addition, we compare the laboratory findings of different severity levels (neutrophil levels <0.2 × 10³/mL, 0.2 × 10³-0.5 × 10³/mL, 0.5 × 10³- 1 × 10³/mL, 1 × 10³- 1.5 × 10³/mL). Methodology: This retrospective study included children with neutropenia (neutrophil < 1.5 × 10³/mL) diagnosed between December 2019-November 2020 in a tertiary hospital. The patients aged between one month-eighteen year had no history of chronic disease, immunosuppressive therapy, malignancy, or drug administration. Ministry of Health's ethics committee approved the study. We evaluated the etiologies and compared age, sex, time of follow-up, duration of neutropenia, thrombocyte, monocyte and immunglobulin levels of neutrophil levels (<0.2 × 10³/mL, 0.2 × 10³-0.5 × 10³/mL, 0.5 × 10³- 1 × 10³/mL, 1 × 10³- 1.5 × 10³/mL). Results: The most common etiology was acute neutropenia (81.5%) and infections (66%). Five (2.5%) had coronavirus disease. Chronic and autoimmune neutropenia are the most common in chronic neutropenia. Lower neutrophils are associated with prolonged neutropenia (p=0.003), higher monocyte (0.03), higher IgM levels (0.038), younger ages (p<0.001), higher IgG (p=0.002) levels. Sex, time of follow-up, thrombocyte levels, total IgE levels are similar in children with different neutrophil counts. Conclusion: Our study demonstrates the etiology in children with neutropenia. The most common etiology is acute neutropenia with infections. In SARS-CoV2 diseases, neutropenia is less common than other hematologic findings. However, we detected in two point five percent of all. Unknown etiologies are also seen in the acute setting. Immun neutropenia and chronic idiopathic neutropenia are the leading causes of chronic cases. IgM levels were higher than the standard ranges in the agranulocytosis group, with a mean age of 1,05 ± 0,80. Therefore, children with ages of one-two should be carefully checked and followed for immunodeficiencies.Hatice Mine CakmakOmer KartalElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S24- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Hatice Mine Cakmak Omer Kartal MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN
description	Objective: Immun-component children with moderate neutropenia do not have an increased risk for severe bacterial infections. However, there is limited data for the management of benign neutropenia in children. Therefore, we aimed to determine the most common etiology and outcomes in children with neutropenia. In addition, we compare the laboratory findings of different severity levels (neutrophil levels <0.2 × 10³/mL, 0.2 × 10³-0.5 × 10³/mL, 0.5 × 10³- 1 × 10³/mL, 1 × 10³- 1.5 × 10³/mL). Methodology: This retrospective study included children with neutropenia (neutrophil < 1.5 × 10³/mL) diagnosed between December 2019-November 2020 in a tertiary hospital. The patients aged between one month-eighteen year had no history of chronic disease, immunosuppressive therapy, malignancy, or drug administration. Ministry of Health's ethics committee approved the study. We evaluated the etiologies and compared age, sex, time of follow-up, duration of neutropenia, thrombocyte, monocyte and immunglobulin levels of neutrophil levels (<0.2 × 10³/mL, 0.2 × 10³-0.5 × 10³/mL, 0.5 × 10³- 1 × 10³/mL, 1 × 10³- 1.5 × 10³/mL). Results: The most common etiology was acute neutropenia (81.5%) and infections (66%). Five (2.5%) had coronavirus disease. Chronic and autoimmune neutropenia are the most common in chronic neutropenia. Lower neutrophils are associated with prolonged neutropenia (p=0.003), higher monocyte (0.03), higher IgM levels (0.038), younger ages (p<0.001), higher IgG (p=0.002) levels. Sex, time of follow-up, thrombocyte levels, total IgE levels are similar in children with different neutrophil counts. Conclusion: Our study demonstrates the etiology in children with neutropenia. The most common etiology is acute neutropenia with infections. In SARS-CoV2 diseases, neutropenia is less common than other hematologic findings. However, we detected in two point five percent of all. Unknown etiologies are also seen in the acute setting. Immun neutropenia and chronic idiopathic neutropenia are the leading causes of chronic cases. IgM levels were higher than the standard ranges in the agranulocytosis group, with a mean age of 1,05 ± 0,80. Therefore, children with ages of one-two should be carefully checked and followed for immunodeficiencies.
format	article
author	Hatice Mine Cakmak Omer Kartal
author_facet	Hatice Mine Cakmak Omer Kartal
author_sort	Hatice Mine Cakmak
title	MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN
title_short	MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN
title_full	MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN
title_fullStr	MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN
title_full_unstemmed	MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN
title_sort	management and outcomes of neutropenia in previously healthy children
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/82cd836e70064c228f9cb1f65dbe4417
work_keys_str_mv	AT haticeminecakmak managementandoutcomesofneutropeniainpreviouslyhealthychildren AT omerkartal managementandoutcomesofneutropeniainpreviouslyhealthychildren
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MANAGEMENT AND OUTCOMES OF NEUTROPENIA IN PREVIOUSLY HEALTHY CHILDREN

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