To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients

Abstract The purpose of this study was to prevent anaemia caused on long-term phenytoin treatment among Epileptic patients. Therefore, two groups were categorised based on the duration of phenytoin namely, cases and control. The duration of Phenytoin treatment for case was > 2 years while control...

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Autores principales:	M. Kathiravan, S. Kavitha, R. Shanthi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/82cd987aaa124de389c9c887e65b0de2
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spelling	oai:doaj.org-article:82cd987aaa124de389c9c887e65b0de22021-12-02T14:28:17ZTo determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients10.1038/s41598-021-83312-y2045-2322https://doaj.org/article/82cd987aaa124de389c9c887e65b0de22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83312-yhttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to prevent anaemia caused on long-term phenytoin treatment among Epileptic patients. Therefore, two groups were categorised based on the duration of phenytoin namely, cases and control. The duration of Phenytoin treatment for case was > 2 years while control had < 1 year. The estimation of serum Folate and Vitamin B12 was carried out and the association between the deficiency of Vitamins with the duration of treatment were evaluated using Linear Regression Analysis. The statistical results shown that the mean value of Folate (2.61 ± 1.81) and the mean value of Vitamin B12 (284.68 ± 110.12) were considered to be low as the duration of Phenytoin treatment increases (> 2 years) compare to control with the Folate concentration of (7.01 ± 4.40) which was statistically significant (p < 0.000). The experimental results have proved that a long-term phenytoin treatment significantly affects the concentration of Folate and Vitamin B12 among the Epileptic patients vigorously.M. KathiravanS. KavithaR. ShanthiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Kathiravan S. Kavitha R. Shanthi To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients
description	Abstract The purpose of this study was to prevent anaemia caused on long-term phenytoin treatment among Epileptic patients. Therefore, two groups were categorised based on the duration of phenytoin namely, cases and control. The duration of Phenytoin treatment for case was > 2 years while control had < 1 year. The estimation of serum Folate and Vitamin B12 was carried out and the association between the deficiency of Vitamins with the duration of treatment were evaluated using Linear Regression Analysis. The statistical results shown that the mean value of Folate (2.61 ± 1.81) and the mean value of Vitamin B12 (284.68 ± 110.12) were considered to be low as the duration of Phenytoin treatment increases (> 2 years) compare to control with the Folate concentration of (7.01 ± 4.40) which was statistically significant (p < 0.000). The experimental results have proved that a long-term phenytoin treatment significantly affects the concentration of Folate and Vitamin B12 among the Epileptic patients vigorously.
format	article
author	M. Kathiravan S. Kavitha R. Shanthi
author_facet	M. Kathiravan S. Kavitha R. Shanthi
author_sort	M. Kathiravan
title	To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients
title_short	To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients
title_full	To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients
title_fullStr	To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients
title_full_unstemmed	To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients
title_sort	to determine the effect of long-term antiepileptic drug on the serum folate and vitamin b12 among epileptic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82cd987aaa124de389c9c887e65b0de2
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To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients

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