Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System

Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neuro...

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Autores principales:	Haofuzi Zhang, Xin Li, Dan Liao, Peng Luo, Xiaofan Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ABHD6 endocannabinoid system CPT1C AMPA receptor neurological diseases Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/82d2529220814ac086b15f4bd8538bf6
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spelling	oai:doaj.org-article:82d2529220814ac086b15f4bd8538bf62021-12-02T12:58:19ZAlpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System1663-981210.3389/fphar.2021.784202https://doaj.org/article/82d2529220814ac086b15f4bd8538bf62021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.784202/fullhttps://doaj.org/toc/1663-9812Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neurotransmission, inflammation, brain energy metabolism, tumorigenesis and other biological processes and is a potential therapeutic target for various neurological diseases, such as traumatic brain injury (TBI), multiple sclerosis (MS), epilepsy, mental illness, and pain. This review summarizes the molecular mechanisms of action and biological functions of ABHD6, particularly its mechanism of action in the pathogenesis of neurological diseases, and provides a theoretical basis for new pharmacological interventions via targeting of ABHD6.Haofuzi ZhangXin LiDan LiaoPeng LuoXiaofan JiangFrontiers Media S.A.articleABHD6endocannabinoid systemCPT1CAMPA receptorneurological diseasesTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ABHD6 endocannabinoid system CPT1C AMPA receptor neurological diseases Therapeutics. Pharmacology RM1-950
spellingShingle	ABHD6 endocannabinoid system CPT1C AMPA receptor neurological diseases Therapeutics. Pharmacology RM1-950 Haofuzi Zhang Xin Li Dan Liao Peng Luo Xiaofan Jiang Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
description	Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neurotransmission, inflammation, brain energy metabolism, tumorigenesis and other biological processes and is a potential therapeutic target for various neurological diseases, such as traumatic brain injury (TBI), multiple sclerosis (MS), epilepsy, mental illness, and pain. This review summarizes the molecular mechanisms of action and biological functions of ABHD6, particularly its mechanism of action in the pathogenesis of neurological diseases, and provides a theoretical basis for new pharmacological interventions via targeting of ABHD6.
format	article
author	Haofuzi Zhang Xin Li Dan Liao Peng Luo Xiaofan Jiang
author_facet	Haofuzi Zhang Xin Li Dan Liao Peng Luo Xiaofan Jiang
author_sort	Haofuzi Zhang
title	Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
title_short	Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
title_full	Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
title_fullStr	Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
title_full_unstemmed	Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
title_sort	alpha/beta-hydrolase domain-containing 6: signaling and function in the central nervous system
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/82d2529220814ac086b15f4bd8538bf6
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Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System

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