IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures

IgG4-related disease is a recently recognized autoimmune systemic disorder that has been described in various organs. The disease is characterized histologically by a dense lymphoplasmacytic infiltrate with IgG4-positive cells, storiform fibrosis, obliterative phlebitis, and can be associated with s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Catarina Correia, Hélder Moreira, Nuno Almeida, Marta Soares, Augusta Cipriano, Pedro Figueiredo
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	igg4 doença relacionada com igg4 estenose crónica Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/82d319a3719145a8bd360448fd35bfd3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:82d319a3719145a8bd360448fd35bfd3
record_format	dspace
spelling	oai:doaj.org-article:82d319a3719145a8bd360448fd35bfd32021-12-02T12:40:23ZIgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures2341-45452387-195410.1159/000520271https://doaj.org/article/82d319a3719145a8bd360448fd35bfd32021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520271https://doaj.org/toc/2341-4545https://doaj.org/toc/2387-1954IgG4-related disease is a recently recognized autoimmune systemic disorder that has been described in various organs. The disease is characterized histologically by a dense lymphoplasmacytic infiltrate with IgG4-positive cells, storiform fibrosis, obliterative phlebitis, and can be associated with space-occupying lesions. IgG4-related disease involving the upper gastrointestinal tract is rare. We report the case of a 30-year-old female patient with a long-standing history of severe dysphagia and odynophagia. Symptoms persisted despite anti-acid therapy, and control esophagogastroduodenoscopy revealed endoscopic images consistent with a nontransposable stenosis in the proximal esophagus. An underlying autoimmune process was suspected, and topical immunosuppressants were tried to control her disease. The patient maintained disabling dysphagia secondary to chronic esophageal strictures. A diagnosis of probable IgG4-related disease was made after esophageal biopsies. Treatment attempts with topical corticosteroids was not associated with a significant improvement of the symptoms of dysphagia and odynophagia, possibly because of the chronic nature of the disease associated with a high fibrotic component. This report describes a case of IgG4-related esophageal disease presenting as chronic esophagitis with strictures. We also briefly review the main histopathological features and treatment options in IgG4-related disease.Catarina CorreiaHélder MoreiraNuno AlmeidaMarta SoaresAugusta CiprianoPedro FigueiredoKarger Publishersarticleigg4doença relacionada com igg4estenose crónicaDiseases of the digestive system. GastroenterologyRC799-869ENGE: Portuguese Journal of Gastroenterology, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	igg4 doença relacionada com igg4 estenose crónica Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	igg4 doença relacionada com igg4 estenose crónica Diseases of the digestive system. Gastroenterology RC799-869 Catarina Correia Hélder Moreira Nuno Almeida Marta Soares Augusta Cipriano Pedro Figueiredo IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures
description	IgG4-related disease is a recently recognized autoimmune systemic disorder that has been described in various organs. The disease is characterized histologically by a dense lymphoplasmacytic infiltrate with IgG4-positive cells, storiform fibrosis, obliterative phlebitis, and can be associated with space-occupying lesions. IgG4-related disease involving the upper gastrointestinal tract is rare. We report the case of a 30-year-old female patient with a long-standing history of severe dysphagia and odynophagia. Symptoms persisted despite anti-acid therapy, and control esophagogastroduodenoscopy revealed endoscopic images consistent with a nontransposable stenosis in the proximal esophagus. An underlying autoimmune process was suspected, and topical immunosuppressants were tried to control her disease. The patient maintained disabling dysphagia secondary to chronic esophageal strictures. A diagnosis of probable IgG4-related disease was made after esophageal biopsies. Treatment attempts with topical corticosteroids was not associated with a significant improvement of the symptoms of dysphagia and odynophagia, possibly because of the chronic nature of the disease associated with a high fibrotic component. This report describes a case of IgG4-related esophageal disease presenting as chronic esophagitis with strictures. We also briefly review the main histopathological features and treatment options in IgG4-related disease.
format	article
author	Catarina Correia Hélder Moreira Nuno Almeida Marta Soares Augusta Cipriano Pedro Figueiredo
author_facet	Catarina Correia Hélder Moreira Nuno Almeida Marta Soares Augusta Cipriano Pedro Figueiredo
author_sort	Catarina Correia
title	IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures
title_short	IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures
title_full	IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures
title_fullStr	IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures
title_full_unstemmed	IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures
title_sort	igg4-related esophageal disease presenting as esophagitis with chronic strictures
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/82d319a3719145a8bd360448fd35bfd3
work_keys_str_mv	AT catarinacorreia igg4relatedesophagealdiseasepresentingasesophagitiswithchronicstrictures AT heldermoreira igg4relatedesophagealdiseasepresentingasesophagitiswithchronicstrictures AT nunoalmeida igg4relatedesophagealdiseasepresentingasesophagitiswithchronicstrictures AT martasoares igg4relatedesophagealdiseasepresentingasesophagitiswithchronicstrictures AT augustacipriano igg4relatedesophagealdiseasepresentingasesophagitiswithchronicstrictures AT pedrofigueiredo igg4relatedesophagealdiseasepresentingasesophagitiswithchronicstrictures
_version_	1718393748809842688

IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures

Ejemplares similares