Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs
Abstract Mesenchymal stem cells (MSCs) hold promise for cartilage engineering. Here, we aimed to determine the best culture conditions to induce chondrogenesis of MSCs isolated from bone marrow (BM) of aged osteoarthritis (OA) patients. We showed that these BM-MSCs proliferate slowly, are not unifor...
Enregistré dans:
Auteurs principaux: | Florence Legendre, David Ollitrault, Tangni Gomez-Leduc, Mouloud Bouyoucef, Magalie Hervieu, Nicolas Gruchy, Frédéric Mallein-Gerin, Sylvain Leclercq, Magali Demoor, Philippe Galéra |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/82d6b1bbe1f74d39bee2a4236a55d4f9 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4
par: Mary Mansilla, et autres
Publié: (2021) -
Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells
par: Sabine Bernegger, et autres
Publié: (2021) -
YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.
par: Rainer Schmid, et autres
Publié: (2013) -
Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epithelia.
par: Martin Löwer, et autres
Publié: (2011) -
Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket.
par: Pruthvi Raj Bejugam, et autres
Publié: (2013)