Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis

Objective: We present the largest population based study of sinonasal squamous cell carcinoma (SCC) to identify risk factors for presentation with nodal metastasis. Methods: The National Cancer Database (NCDB) was used for this study. Location codes corresponding to the nasal cavity and paranasal si...

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Autores principales:	Viran J. Ranasinghe, Vanessa C. Stubbs, Danielle C. Reny, Ramie Fathy, Jason A. Brant, Jason G. Newman
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Squamous cell carcinoma National cancer database Nodal metastasis Maxillary sinus Nasal cavity Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/82d7ccf1498c433899945c1d4983a921
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spelling	oai:doaj.org-article:82d7ccf1498c433899945c1d4983a9212021-12-02T13:48:38ZPredictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis2095-881110.1016/j.wjorl.2020.01.006https://doaj.org/article/82d7ccf1498c433899945c1d4983a9212020-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881120300226https://doaj.org/toc/2095-8811Objective: We present the largest population based study of sinonasal squamous cell carcinoma (SCC) to identify risk factors for presentation with nodal metastasis. Methods: The National Cancer Database (NCDB) was used for this study. Location codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy were queried. Logistic regression analysis was performed to identify factors associated with presentation with nodal metastasis. Results: 6448 cases met inclusion criteria. Nodal metastasis at presentation was seen in 13.2% of patients, with the sinus subsite (19.3%) being a significant risk factor for nodal metastasis at presentation when compared to the nasal cavity (7.9%). Logistic regression analysis showed black, uninsured and Medicaid patients were more likely than white and privately insured patients, respectively, to present with nodal metastasis. Conclusions: In sinonasal SCC, the sinus subsite has a significantly increased risk of nodal metastasis compared to the nasal cavity. Black race, uninsured and Medicaid patients are more likely to have nodal metastasis at presentation.Viran J. RanasingheVanessa C. StubbsDanielle C. RenyRamie FathyJason A. BrantJason G. NewmanKeAi Communications Co., Ltd.articleSquamous cell carcinomaNational cancer databaseNodal metastasisMaxillary sinusNasal cavityOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 6, Iss 2, Pp 137-141 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Squamous cell carcinoma National cancer database Nodal metastasis Maxillary sinus Nasal cavity Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Squamous cell carcinoma National cancer database Nodal metastasis Maxillary sinus Nasal cavity Otorhinolaryngology RF1-547 Surgery RD1-811 Viran J. Ranasinghe Vanessa C. Stubbs Danielle C. Reny Ramie Fathy Jason A. Brant Jason G. Newman Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis
description	Objective: We present the largest population based study of sinonasal squamous cell carcinoma (SCC) to identify risk factors for presentation with nodal metastasis. Methods: The National Cancer Database (NCDB) was used for this study. Location codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy were queried. Logistic regression analysis was performed to identify factors associated with presentation with nodal metastasis. Results: 6448 cases met inclusion criteria. Nodal metastasis at presentation was seen in 13.2% of patients, with the sinus subsite (19.3%) being a significant risk factor for nodal metastasis at presentation when compared to the nasal cavity (7.9%). Logistic regression analysis showed black, uninsured and Medicaid patients were more likely than white and privately insured patients, respectively, to present with nodal metastasis. Conclusions: In sinonasal SCC, the sinus subsite has a significantly increased risk of nodal metastasis compared to the nasal cavity. Black race, uninsured and Medicaid patients are more likely to have nodal metastasis at presentation.
format	article
author	Viran J. Ranasinghe Vanessa C. Stubbs Danielle C. Reny Ramie Fathy Jason A. Brant Jason G. Newman
author_facet	Viran J. Ranasinghe Vanessa C. Stubbs Danielle C. Reny Ramie Fathy Jason A. Brant Jason G. Newman
author_sort	Viran J. Ranasinghe
title	Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis
title_short	Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis
title_full	Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis
title_fullStr	Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis
title_full_unstemmed	Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis
title_sort	predictors of nodal metastasis in sinonasal squamous cell carcinoma: a national cancer database analysis
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/82d7ccf1498c433899945c1d4983a921
work_keys_str_mv	AT viranjranasinghe predictorsofnodalmetastasisinsinonasalsquamouscellcarcinomaanationalcancerdatabaseanalysis AT vanessacstubbs predictorsofnodalmetastasisinsinonasalsquamouscellcarcinomaanationalcancerdatabaseanalysis AT daniellecreny predictorsofnodalmetastasisinsinonasalsquamouscellcarcinomaanationalcancerdatabaseanalysis AT ramiefathy predictorsofnodalmetastasisinsinonasalsquamouscellcarcinomaanationalcancerdatabaseanalysis AT jasonabrant predictorsofnodalmetastasisinsinonasalsquamouscellcarcinomaanationalcancerdatabaseanalysis AT jasongnewman predictorsofnodalmetastasisinsinonasalsquamouscellcarcinomaanationalcancerdatabaseanalysis
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Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis

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