Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer
Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chr...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:82d82a66f0fe42ebb820691c96c018a92021-11-30T11:40:23ZFunctional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer2234-943X10.3389/fonc.2021.777374https://doaj.org/article/82d82a66f0fe42ebb820691c96c018a92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.777374/fullhttps://doaj.org/toc/2234-943XGastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.Yao ChenYao ChenYao ChenWeili LongLiqiong YangLiqiong YangLiqiong YangYueshui ZhaoYueshui ZhaoYueshui ZhaoXu WuXu WuXu WuMingxing LiMingxing LiMingxing LiFukuan DuFukuan DuFukuan DuYu ChenYu ChenYu ChenZhihui YangQinglian WenTao YiZhangang XiaoZhangang XiaoZhangang XiaoJing ShenJing ShenJing ShenFrontiers Media S.A.articlelong non-coding RNA (lncRNA)ORFsmall peptidegastrointestinal cancerfunctionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
long non-coding RNA (lncRNA) ORF small peptide gastrointestinal cancer function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
long non-coding RNA (lncRNA) ORF small peptide gastrointestinal cancer function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yao Chen Yao Chen Yao Chen Weili Long Liqiong Yang Liqiong Yang Liqiong Yang Yueshui Zhao Yueshui Zhao Yueshui Zhao Xu Wu Xu Wu Xu Wu Mingxing Li Mingxing Li Mingxing Li Fukuan Du Fukuan Du Fukuan Du Yu Chen Yu Chen Yu Chen Zhihui Yang Qinglian Wen Tao Yi Zhangang Xiao Zhangang Xiao Zhangang Xiao Jing Shen Jing Shen Jing Shen Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer |
| description |
Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer. |
| format |
article |
| author |
Yao Chen Yao Chen Yao Chen Weili Long Liqiong Yang Liqiong Yang Liqiong Yang Yueshui Zhao Yueshui Zhao Yueshui Zhao Xu Wu Xu Wu Xu Wu Mingxing Li Mingxing Li Mingxing Li Fukuan Du Fukuan Du Fukuan Du Yu Chen Yu Chen Yu Chen Zhihui Yang Qinglian Wen Tao Yi Zhangang Xiao Zhangang Xiao Zhangang Xiao Jing Shen Jing Shen Jing Shen |
| author_facet |
Yao Chen Yao Chen Yao Chen Weili Long Liqiong Yang Liqiong Yang Liqiong Yang Yueshui Zhao Yueshui Zhao Yueshui Zhao Xu Wu Xu Wu Xu Wu Mingxing Li Mingxing Li Mingxing Li Fukuan Du Fukuan Du Fukuan Du Yu Chen Yu Chen Yu Chen Zhihui Yang Qinglian Wen Tao Yi Zhangang Xiao Zhangang Xiao Zhangang Xiao Jing Shen Jing Shen Jing Shen |
| author_sort |
Yao Chen |
| title |
Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer |
| title_short |
Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer |
| title_full |
Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer |
| title_fullStr |
Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer |
| title_full_unstemmed |
Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer |
| title_sort |
functional peptides encoded by long non-coding rnas in gastrointestinal cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/82d82a66f0fe42ebb820691c96c018a9 |
| work_keys_str_mv |
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