DrugHybrid_BS: Using Hybrid Feature Combined With Bagging-SVM to Predict Potentially Druggable Proteins
Drug targets are biological macromolecules or biomolecule structures capable of specifically binding a therapeutic effect with a particular drug or regulating physiological functions. Due to the important value and role of drug targets in recent years, the prediction of potential drug targets has be...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/82de434ac7cc4768ae4a885693cc71a6 |
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| Sumario: | Drug targets are biological macromolecules or biomolecule structures capable of specifically binding a therapeutic effect with a particular drug or regulating physiological functions. Due to the important value and role of drug targets in recent years, the prediction of potential drug targets has become a research hotspot. The key to the research and development of modern new drugs is first to identify potential drug targets. In this paper, a new predictor, DrugHybrid_BS, is developed based on hybrid features and Bagging-SVM to identify potentially druggable proteins. This method combines the three features of monoDiKGap (k = 2), cross-covariance, and grouped amino acid composition. It removes redundant features and analyses key features through MRMD and MRMD2.0. The cross-validation results show that 96.9944% of the potentially druggable proteins can be accurately identified, and the accuracy of the independent test set has reached 96.5665%. This all means that DrugHybrid_BS has the potential to become a useful predictive tool for druggable proteins. In addition, the hybrid key features can identify 80.0343% of the potentially druggable proteins combined with Bagging-SVM, which indicates the significance of this part of the features for research. |
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