Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes

Primary small cell carcinoma of the oesophagus has a poor prognosis, and has not been fully characterised molecularly. Here, the authors study the disease using multi-omics technology and find frequent RB1 disruptions and similarities to small cell lung cancer, opening potential therapeutic avenues.

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Detalles Bibliográficos
Autores principales:	Renda Li, Zhenlin Yang, Fei Shao, Hong Cheng, Yaru Wen, Sijin Sun, Wei Guo, Zitong Li, Fan Zhang, Liyan Xue, Nan Bi, Jie Wang, Yingli Sun, Yin Li, Fengwei Tan, Qi Xue, Shugeng Gao, Susheng Shi, Yibo Gao, Jie He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/82de6a19353d420ea06e6ba8c515d3bc
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spelling	oai:doaj.org-article:82de6a19353d420ea06e6ba8c515d3bc2021-12-02T17:39:56ZMulti-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes10.1038/s41467-021-24043-62041-1723https://doaj.org/article/82de6a19353d420ea06e6ba8c515d3bc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24043-6https://doaj.org/toc/2041-1723Primary small cell carcinoma of the oesophagus has a poor prognosis, and has not been fully characterised molecularly. Here, the authors study the disease using multi-omics technology and find frequent RB1 disruptions and similarities to small cell lung cancer, opening potential therapeutic avenues.Renda LiZhenlin YangFei ShaoHong ChengYaru WenSijin SunWei GuoZitong LiFan ZhangLiyan XueNan BiJie WangYingli SunYin LiFengwei TanQi XueShugeng GaoSusheng ShiYibo GaoJie HeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renda Li Zhenlin Yang Fei Shao Hong Cheng Yaru Wen Sijin Sun Wei Guo Zitong Li Fan Zhang Liyan Xue Nan Bi Jie Wang Yingli Sun Yin Li Fengwei Tan Qi Xue Shugeng Gao Susheng Shi Yibo Gao Jie He Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
description	Primary small cell carcinoma of the oesophagus has a poor prognosis, and has not been fully characterised molecularly. Here, the authors study the disease using multi-omics technology and find frequent RB1 disruptions and similarities to small cell lung cancer, opening potential therapeutic avenues.
format	article
author	Renda Li Zhenlin Yang Fei Shao Hong Cheng Yaru Wen Sijin Sun Wei Guo Zitong Li Fan Zhang Liyan Xue Nan Bi Jie Wang Yingli Sun Yin Li Fengwei Tan Qi Xue Shugeng Gao Susheng Shi Yibo Gao Jie He
author_facet	Renda Li Zhenlin Yang Fei Shao Hong Cheng Yaru Wen Sijin Sun Wei Guo Zitong Li Fan Zhang Liyan Xue Nan Bi Jie Wang Yingli Sun Yin Li Fengwei Tan Qi Xue Shugeng Gao Susheng Shi Yibo Gao Jie He
author_sort	Renda Li
title	Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
title_short	Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
title_full	Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
title_fullStr	Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
title_full_unstemmed	Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
title_sort	multi-omics profiling of primary small cell carcinoma of the esophagus reveals rb1 disruption and additional molecular subtypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82de6a19353d420ea06e6ba8c515d3bc
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Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes

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