High-throughput interrogation of programmed ribosomal frameshifting in human cells

Programmed ribosomal frameshifting—the slippage of the ribosome to an alternative frame — is critical for viral replication and cellular processes. Here the authors present an approach that can assess the frameshifting potential of a sequence and elucidate the rules governing ribosomal frameshifting...

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Auteurs principaux:	Martin Mikl, Yitzhak Pilpel, Eran Segal
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/82e2217d97d24ceda90271fe670fb62c
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id	oai:doaj.org-article:82e2217d97d24ceda90271fe670fb62c
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spelling	oai:doaj.org-article:82e2217d97d24ceda90271fe670fb62c2021-12-02T17:23:25ZHigh-throughput interrogation of programmed ribosomal frameshifting in human cells10.1038/s41467-020-16961-82041-1723https://doaj.org/article/82e2217d97d24ceda90271fe670fb62c2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16961-8https://doaj.org/toc/2041-1723Programmed ribosomal frameshifting—the slippage of the ribosome to an alternative frame — is critical for viral replication and cellular processes. Here the authors present an approach that can assess the frameshifting potential of a sequence and elucidate the rules governing ribosomal frameshifting.Martin MiklYitzhak PilpelEran SegalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Mikl Yitzhak Pilpel Eran Segal High-throughput interrogation of programmed ribosomal frameshifting in human cells
description	Programmed ribosomal frameshifting—the slippage of the ribosome to an alternative frame — is critical for viral replication and cellular processes. Here the authors present an approach that can assess the frameshifting potential of a sequence and elucidate the rules governing ribosomal frameshifting.
format	article
author	Martin Mikl Yitzhak Pilpel Eran Segal
author_facet	Martin Mikl Yitzhak Pilpel Eran Segal
author_sort	Martin Mikl
title	High-throughput interrogation of programmed ribosomal frameshifting in human cells
title_short	High-throughput interrogation of programmed ribosomal frameshifting in human cells
title_full	High-throughput interrogation of programmed ribosomal frameshifting in human cells
title_fullStr	High-throughput interrogation of programmed ribosomal frameshifting in human cells
title_full_unstemmed	High-throughput interrogation of programmed ribosomal frameshifting in human cells
title_sort	high-throughput interrogation of programmed ribosomal frameshifting in human cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/82e2217d97d24ceda90271fe670fb62c
work_keys_str_mv	AT martinmikl highthroughputinterrogationofprogrammedribosomalframeshiftinginhumancells AT yitzhakpilpel highthroughputinterrogationofprogrammedribosomalframeshiftinginhumancells AT eransegal highthroughputinterrogationofprogrammedribosomalframeshiftinginhumancells
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High-throughput interrogation of programmed ribosomal frameshifting in human cells

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