Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering

Abstract The adult heart is a vital and highly specialized organ of the human body, with limited capability of self-repair and regeneration in case of injury or disease. Engineering biomimetic cardiac tissue to regenerate the heart has been an ambition in the field of tissue engineering, tracing bac...

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Autores principales:	Miguel F. Tenreiro, Ana F. Louro, Paula M. Alves, Margarida Serra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/82e44137bf2a4c13a2a796924cd5f438
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spelling	oai:doaj.org-article:82e44137bf2a4c13a2a796924cd5f4382021-12-02T15:56:40ZNext generation of heart regenerative therapies: progress and promise of cardiac tissue engineering10.1038/s41536-021-00140-42057-3995https://doaj.org/article/82e44137bf2a4c13a2a796924cd5f4382021-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00140-4https://doaj.org/toc/2057-3995Abstract The adult heart is a vital and highly specialized organ of the human body, with limited capability of self-repair and regeneration in case of injury or disease. Engineering biomimetic cardiac tissue to regenerate the heart has been an ambition in the field of tissue engineering, tracing back to the 1990s. Increased understanding of human stem cell biology and advances in process engineering have provided an unlimited source of cells, particularly cardiomyocytes, for the development of functional cardiac muscle, even though pluripotent stem cell-derived cardiomyocytes poorly resemble those of the adult heart. This review outlines key biology-inspired strategies reported to improve cardiomyocyte maturation features and current biofabrication approaches developed to engineer clinically relevant cardiac tissues. It also highlights the potential use of this technology in drug discovery science and disease modeling as well as the current efforts to translate it into effective therapies that improve heart function and promote regeneration.Miguel F. TenreiroAna F. LouroPaula M. AlvesMargarida SerraNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Miguel F. Tenreiro Ana F. Louro Paula M. Alves Margarida Serra Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
description	Abstract The adult heart is a vital and highly specialized organ of the human body, with limited capability of self-repair and regeneration in case of injury or disease. Engineering biomimetic cardiac tissue to regenerate the heart has been an ambition in the field of tissue engineering, tracing back to the 1990s. Increased understanding of human stem cell biology and advances in process engineering have provided an unlimited source of cells, particularly cardiomyocytes, for the development of functional cardiac muscle, even though pluripotent stem cell-derived cardiomyocytes poorly resemble those of the adult heart. This review outlines key biology-inspired strategies reported to improve cardiomyocyte maturation features and current biofabrication approaches developed to engineer clinically relevant cardiac tissues. It also highlights the potential use of this technology in drug discovery science and disease modeling as well as the current efforts to translate it into effective therapies that improve heart function and promote regeneration.
format	article
author	Miguel F. Tenreiro Ana F. Louro Paula M. Alves Margarida Serra
author_facet	Miguel F. Tenreiro Ana F. Louro Paula M. Alves Margarida Serra
author_sort	Miguel F. Tenreiro
title	Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
title_short	Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
title_full	Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
title_fullStr	Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
title_full_unstemmed	Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
title_sort	next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/82e44137bf2a4c13a2a796924cd5f438
work_keys_str_mv	AT miguelftenreiro nextgenerationofheartregenerativetherapiesprogressandpromiseofcardiactissueengineering AT anaflouro nextgenerationofheartregenerativetherapiesprogressandpromiseofcardiactissueengineering AT paulamalves nextgenerationofheartregenerativetherapiesprogressandpromiseofcardiactissueengineering AT margaridaserra nextgenerationofheartregenerativetherapiesprogressandpromiseofcardiactissueengineering
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Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering

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